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Trial finds Deucravacitinib is Effective For Moderate to Severe Plaque Psoriasis


Clinical trial reveals promising new treatment for plaque psoriasis

Plaque psoriasis is a chronic skin condition that causes the skin to become red, thick, and scaly. It is the most common type of psoriasis, accounting for about 80% of all psoriasis cases. Plaque psoriasis occurs when the immune system mistakenly attacks healthy skin cells, causing them to grow too quickly and build up on the surface of the skin. This leads to the formation of thick, silvery scales and red patches on the skin that can be itchy, painful, and can crack and bleed.

Severe plaque psoriasis is characterized by extensive skin involvement, covering more than 10% of the body surface area, and can significantly impact a person's quality of life. It may require more aggressive treatment options, including systemic medications, to control symptoms and prevent complications.

Clinical Trial

Deucravacitinib, an oral, selective, allosteric tyrosine kinase two inhibitor, is a new psoriasis treatment evaluated for efficacy and safety in adults with moderate to severe plaque psoriasis. The study was a 52-week, double-blinded, phase 3 trial that compared deucravacitinib with a placebo and apremilast. The primary endpoints were response rates for ≥75% reduction from baseline in Psoriasis Area and Severity Index (PASI 75) and static Physician's Global Assessment score of 0 or 1 (sPGA 0/1) with deucravacitinib versus placebo at week 16.

The results showed that at week 16, response rates were significantly higher with deucravacitinib versus placebo or apremilast for PASI 75 and sPGA 0/1. Moreover, the drug's efficacy improved beyond week 16 and was maintained through week 52. Adverse event rates with deucravacitinib were similar to those with placebo and apremilast, indicating that the patients tolerated it well.

The study suggests that deucravacitinib is an effective and safe treatment option for patients with moderate to severe plaque psoriasis. The drug showed superior efficacy to placebo and apremilast across multiple efficacy endpoints.


In conclusion, the study provides evidence that deucravacitinib is a promising new treatment for psoriasis that may benefit patients seeking effective, well-tolerated oral psoriasis treatments. Further studies may be needed to explore the long-term safety and efficacy of deucravacitinib in a more diverse patient population.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.