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Sitagliptin plus Phototherapy, A Promising Treatment for Psoriasis


Clinical trial shows combining sitagliptin with phototherapy is effective treatment for moderate psoriasis

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor that is commonly used to treat type 2 diabetes mellitus (T2DM), has been reported to improve psoriasis. In a clinical trial, researchers investigated whether combining sitagliptin with narrow-band ultraviolet-B (NB-UVB) phototherapy could provide better results for people with moderate psoriasis who do not have T2DM.

Psoriasis is a chronic autoimmune condition that affects approximately 2% of the world's population. It causes skin cells to grow too quickly, resulting in scaly patches and itchiness. While there is no cure for psoriasis, treatments like NB-UVB phototherapy can help alleviate symptoms.

Clinical trial

The trial involved 118 people with moderate psoriasis who were randomly assigned to receive either sitagliptin and NB-UVB phototherapy or NB-UVB phototherapy alone. The primary endpoint was the change in Psoriasis Area and Severity Index (PASI) from baseline to 24 weeks.

After 24 weeks, the researchers found that the combination therapy group experienced a significantly larger reduction in PASI scores than the NB-UVB phototherapy alone group. The combination therapy group also had significant improvements in quality of life, as measured by the Hospital Anxiety and Depression Scale and the EuroQol 5-item questionnaire.

Moreover, the combination therapy group did not experience any serious adverse events related to treatment.

These findings suggest that sitagliptin therapy combined with NB-UVB phototherapy can provide modest improvements in psoriasis severity and quality of life for people with moderate psoriasis who do not have T2DM.

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Psoriasis can have a significant impact on a person's physical and emotional well-being. In addition to skin symptoms, people with psoriasis may also experience joint pain and fatigue, which can make it difficult to carry out daily activities. Therefore, finding effective treatments for psoriasis is crucial for improving the lives of those affected by this condition.

NB-UVB phototherapy is a well-established treatment for psoriasis, but combining it with sitagliptin may provide additional benefits. Sitagliptin works by inhibiting DPP-4, an enzyme that breaks down a hormone called glucagon-like peptide-1 (GLP-1). GLP-1 plays a role in regulating blood sugar levels and is also involved in the immune system.

By inhibiting DPP-4, sitagliptin can increase the levels of GLP-1 in the body. This, in turn, may help regulate the immune system and reduce inflammation, which are both key factors in psoriasis.


Overall, the results of this clinical trial provide evidence that combining sitagliptin with NB-UVB phototherapy can be a safe and effective treatment option for people with moderate psoriasis who do not have T2DM. While the improvements in psoriasis severity and quality of life were modest, they may still be significant for those affected by this condition.

If you have psoriasis and are interested in trying sitagliptin therapy in combination with NB-UVB phototherapy, talk to your healthcare provider. They can help determine whether this treatment is appropriate for you and provide guidance on how to manage your psoriasis symptoms.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.