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The Benefits of Advanced Hybrid Closed Loop System for Type 1 Diabetes

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Clinical trial reveals the advanced hybrid closed loop system is the most effective for controlling blood sugar in type 1 diabetic adults

Type 1 diabetes is a chronic condition that affects millions of people around the world. It occurs when the body is unable to produce enough insulin, which is a hormone that helps regulate blood sugar levels. People with type 1 diabetes have to manage their condition carefully, which can be challenging and time-consuming. One of the main treatments for type 1 diabetes is insulin therapy, which involves injecting insulin into the body to help regulate blood sugar levels.

While insulin therapy is effective, it is not always enough to keep blood sugar levels within the normal range. In some cases, people with type 1 diabetes may need additional treatments to help them manage their condition. One such treatment is called continuous glucose monitoring (CGM), which involves wearing a device that continuously measures blood sugar levels. Another treatment is called a closed-loop system, which uses a CGM device to automatically adjust insulin delivery based on blood sugar levels.

Clinical Trial

A clinical trial aimed to test the effectiveness of an advanced hybrid closed loop (AHCL) system compared to insulin therapy and intermittent CGM in adults with type 1 diabetes. The trial involved 14 centers in three European countries and enrolled participants who were at least 18 years old, had a type 1 diabetes duration of at least 2 years, and had an HbA1c of at least 8% (which indicates poor blood sugar control).

The trial randomly chose people to use one of two treatments for 6 months: the AHCL system or insulin therapy with CGM. The main thing the researchers wanted to find out was how the two treatments affected the average HbA1c levels of the participants after 6 months. They also looked at how safe the treatments were by checking for device problems, severely low blood sugar, diabetic ketoacidosis, and other serious problems.

Results

The trial found that participants who used the AHCL system had significantly better blood sugar control than those who used insulin therapy and CGM. At 6 months, the mean HbA1c had decreased by 1.54% in the AHCL group, compared to only 0.20% in the insulin therapy and CGM group. This means that the AHCL system helped people with type 1 diabetes achieve better blood sugar control than insulin therapy and CGM alone.

The study also found that the AHCL system was safe to use, with no severe hypoglycemic events, diabetic ketoacidosis, or serious adverse events related to the study devices. There were some device-related non-serious adverse events in the AHCL group, but these were not significant. Two serious adverse events occurred, but they were not related to the study devices.

Overall, the results of the study suggest that the AHCL system may be a promising treatment option for people with type 1 diabetes who are struggling to manage their blood sugar levels. While the AHCL system is not a cure for type 1 diabetes, it may help people achieve better blood sugar control and improve their quality of life. It is important to note that the trial only included adults with type 1 diabetes and that further research is needed to determine the effectiveness of the AHCL system in children and adolescents with the condition.

Conclusion

The clinical trial found that the AHCL system was more effective than insulin therapy and CGM alone in improving blood sugar control in adults with type 1 diabetes. The AHCL system was also safe to use, with no severe adverse events related to the study devices. These findings suggest that the AHCL system may be a promising treatment option for people with type 1 diabetes who are struggling to manage their condition. However, further research is needed to determine the effectiveness of the AHCL system in children and adolescents with the condition.

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THE LANCET, Sep-01-22


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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.