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A Clinical Trial evaluates MRI-Guided Fibrosis Ablation for Persistent Atrial Fibrillation


Clinical trial shows MRI-guided fibrosis ablation is less safe for A-Fib patients

Atrial fibrillation (AF) is a heart condition that affects millions of people worldwide. It is a type of arrhythmia, which is an irregular heartbeat that occurs when the heart's electrical signals don't function properly. In AF, the atria, which are the upper chambers of the heart, quiver or contract rapidly and irregularly, which can lead to an irregular and often rapid heartbeat in the lower chambers of the heart, the ventricles.

AF can be a serious condition and can cause a variety of symptoms, including heart palpitations, shortness of breath, chest pain, and fatigue. It can also lead to complications such as blood clots, stroke, heart failure, and other cardiovascular diseases.

Persistent AF is a type of AF that lasts for more than 7 days or requires medical treatment to stop. Doctors treat persistent AF with a procedure called catheter ablation. During this procedure, a doctor uses a catheter to create tiny scars in the heart tissue that block the abnormal electrical signals causing AF. However, even with this procedure, some patients still experience AF symptoms.

To try and improve the success rate of catheter ablation, doctors have been studying a technique called magnetic resonance imaging (MRI)-guided fibrosis ablation. This technique involves using MRI scans to identify areas of fibrosis (scarring) in the heart that could be contributing to AF. Then, during catheter ablation, the doctor uses radiofrequency energy to destroy these areas of fibrosis.

Clinical Trial

To determine if MRI-guided fibrosis ablation is an effective treatment for persistent AF, researchers conducted a clinical trial involving 843 patients from 10 different countries. The patients were randomly assigned to receive either conventional catheter ablation alone or catheter ablation with MRI-guided fibrosis ablation.


The researchers found that there was no significant difference in the recurrence of AF between the two groups. This means that MRI-guided fibrosis ablation did not improve the success rate of catheter ablation. Additionally, patients who received MRI-guided fibrosis ablation had a higher rate of safety problems, including stroke and death.


The findings of this clinical trial do not support the use of MRI-guided fibrosis ablation for the treatment of persistent AF. While this technique may seem promising, it does not appear to be effective in improving the success rate of catheter ablation and may actually increase the risk of complications.

If you or a loved one has persistent AF, talk to your doctor about the best treatment options available. There are many effective treatments for AF, including medication, catheter ablation, and surgery. Your doctor can help you decide which treatment is right for you based on your individual needs and health status.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.