CenTrial Logo

What is the best Perfusion Method for Congenital Heart Surgery?

by


Clinical trial compares perfusion methods for congential heart surgery

Congenital heart disease refers to a group of heart conditions that develop before birth. It occurs when the heart or blood vessels around the heart don't form properly during fetal development. The severity of congenital heart disease can range from mild, where it may not even require treatment, to severe, where it can lead to life-threatening complications.

The causes of congenital heart disease are often unknown, but genetics, infections, and environmental factors can all play a role. Advances in medical technology and surgical techniques have improved the survival rate and quality of life for individuals with congenital heart disease. However, it remains a significant health concern, affecting approximately 1% of all live births globally.

While advances in technology have led to improvements in surgical techniques, it is still important to investigate the effects of perfusion modalities on cerebral hemodynamics, vital organ injury, and clinical outcomes. This randomized clinical trial aimed to investigate these effects in risk-stratified congenital cardiac surgery patients.

Clinical trial

The trial included 159 consecutive congenital cardiac surgery patients, half of whom received pulsatile perfusion and half of whom received non-pulsatile perfusion. Cerebral hemodynamics were assessed using transcranial Doppler ultrasound, and multiple organ injury was quantified using the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score at 24, 48, and 72 hours. Clinical outcomes, including intubation time, intensive care unit length of stay (LOS), hospital LOS, and mortality, were also evaluated.

Results

The results of the trial showed that the Pulsatility Index at the middle cerebral artery and in the arterial line during aortic cross-clamping was consistently better maintained in the pulsatile group. While there were no differences in clinical outcomes between the two groups, the PELOD-2 scores showed a progressive improvement from 24 hours to 72 hours, but the results were not statistically different between the groups.

It is important to note that while the Pulsatility Index for the pulsatile group demonstrated a more physiologic pattern compared with the non-pulsatile group, pulsatile perfusion did not increase plasma-free hemoglobin levels or microemboli delivery. Therefore, the trial results suggest that while pulsatile perfusion is a safe method, it is not a “magic bullet” for congenital cardiac operations.

Conclusion

This clinical trial provides valuable information on the effects of perfusion methods on cerebral hemodynamics, vital organ injury, and clinical outcomes in congenital cardiac surgery patients. While there were no significant differences in clinical outcomes between pulsatile and non-pulsatile perfusion, the trial results suggest that pulsatile perfusion may have some advantages in maintaining the Pulsatility Index at the middle cerebral artery and in the arterial line during aortic cross-clamping. It is important to continue investigating the effects of perfusion modalities on congenital cardiac surgery patients to improve surgical techniques and patient outcomes.
__________


Share this article with a friend:
     

Get emailed clinical trial results in the categories of your choice:
Free Subscription

Without participants there can be no clinical trials.
Without clinical trials there will be no new treatments.
Signup to be notified of a clinical trial near you.
Free Notification


This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.