CenTrial Logo

Effective Strategies for Managing Insomnia: Medicinal Cannabis Oil


Clinical trial shows that cannabis oil improved melatonin levels and sleep quality in insomnia patients

Insomnia, a condition where people have difficulty falling asleep or staying asleep, is quite common, affecting as many as 30% of people in the general population.

Clinical Trial

Scientists conducted a clinical trial to understand how cannabis oil called Entoura-10:15 might help adults with insomnia. In this study, 29 participants who reported having clinical insomnia took part. They were divided into two groups: one group received a placebo (a substance with no therapeutic effect), while the other group received the active Entoura-10:15 medicinal cannabis oil. This oil contained two important compounds: 10 mg/ml of tetrahydrocannabinol (THC) and 15 mg/ml of cannabidiol (CBD). Over two weeks, participants gradually increased their daily oil dose, ranging from 0.2 to 1.5 ml. After this, there was a one-week break before they switched to the other group to ensure accurate results.

The participants kept a daily diary to record their experiences. Most participants tolerated the Entoura-10:15 medicinal cannabis oil quite well.

The researchers looked at midnight melatonin levels in participants' saliva. Melatonin is a hormone that helps regulate sleep-wake cycles, and the levels significantly improved in the group that received the active oil. This improvement was 30%, while the placebo group saw a decline of 20%.

Are you interested in clinical trials near you?

You can receive free notification of a trial for this, or any other condition, by completing a short confidential health profile.
Find a clinical trial near me

Sleep Quality

The researchers used questionnaires like the Insomnia Severity Index to understand the participants' sleep quality better. The results showed that 60% of those who received the medicinal cannabis oil no longer met the criteria for clinical insomnia at the end of the 2-week treatment period.

The study also used Fitbit activity/sleep wrist trackers to monitor sleep patterns. People taking the medicinal cannabis oil experienced improvements in both the duration and quality of their sleep. They enjoyed an additional 21 minutes of light sleep each night compared to the placebo group. The overall sleep quality improved by up to 80% in the active group, including their daily functioning.


This study suggests that Entoura-10:15 medicinal cannabis oil is well-tolerated and effective in improving sleep in adults with insomnia. These findings provide hope for individuals struggling with this common sleep disorder, offering a potential new avenue for treatment. However, further research is needed to confirm and expand upon these results.

Share this article with a friend:

Get emailed clinical trial results in the categories of your choice:
Free subscription to clinical trial results

Without participants there can be no clinical trials.
Without clinical trials there will be no new treatments.
Signup and be matched to trials near you
This free service will notify you of current and future clinical trial matches.

This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.