Insomnia, a condition where people have difficulty falling asleep or staying asleep, is quite common, affecting as many as 30% of people in the general population.
Clinical Trial
Scientists conducted a clinical trial to understand how cannabis oil called Entoura-10:15 might help adults with insomnia. In this study, 29 participants who reported having clinical insomnia took part. They were divided into two groups: one group received a placebo (a substance with no therapeutic effect), while the other group received the active Entoura-10:15 medicinal cannabis oil. This oil contained two important compounds: 10 mg/ml of tetrahydrocannabinol (THC) and 15 mg/ml of cannabidiol (CBD). Over two weeks, participants gradually increased their daily oil dose, ranging from 0.2 to 1.5 ml. After this, there was a one-week break before they switched to the other group to ensure accurate results.The participants kept a daily diary to record their experiences. Most participants tolerated the Entoura-10:15 medicinal cannabis oil quite well.
The researchers looked at midnight melatonin levels in participants' saliva. Melatonin is a hormone that helps regulate sleep-wake cycles, and the levels significantly improved in the group that received the active oil. This improvement was 30%, while the placebo group saw a decline of 20%.