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Safety Study of Upadacitinib in Inflammatory Diseases


Clinical trial finds upadacitinib safe for inflammatory diseases

Immune-mediated inflammatory diseases (IMIDs) are a group of chronic conditions that occur when the body's immune system mistakenly attacks its healthy tissues. This leads to inflammation, pain, and damage to the affected organs or tissues. Some common examples of IMIDs include rheumatoid arthritis (RA), ankylosing spondylitis (AS), atopic dermatitis (AD), ulcerative colitis (UC), psoriasis, Crohn's disease, and multiple sclerosis (MS). These diseases can cause various symptoms, including joint pain, skin rashes, digestive problems, and neurological issues. Treatment for IMIDs often involves medications that suppress the immune system and reduce inflammation. While the exact causes of IMIDs are not fully understood, it is believed that a combination of genetic and environmental factors may play a role.


Upadacitinib is a drug that blocks certain enzymes in the body that cause inflammation. It is taken by mouth and has been studied in clinical trials for several diseases, including RA, psoriatic arthritis (PsA), AS, AD, and UC. The approved dose varies depending on the condition being treated. The approved dose for treating rheumatological diseases is 15mg once a day; 15 and 30mg are approved for moderate-to-severe AD and 45mg for induction therapy for UC.

Clinical Trial Analysis

Researchers analyzed safety data from 12 clinical trials of upadacitinib, which included patients with RA, PsA, AS, and AD. The data included treatment-emergent adverse events and adverse events of special interest for each disease and treatment group. The study looked at 6,991 patients with different types of arthritis. The patients took the drug for up to 5 years.


The study found that the drug was generally safe for all types of arthritis. Still, side effects like herpes zoster and non-melanoma skin cancer were more common in patients with rheumatoid arthritis and psoriatic arthritis. There were incidences of deaths, serious infections, heart problems, or blood clots. These problems were less common in patients with ankylosing spondylitis and atopic dermatitis. Only patients with atopic dermatitis had an increased risk of getting acne.

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The study analyzed the safety of upadacitinib in patients with different types of arthritis and dermatitis. The findings suggest that upadacitinib is generally well tolerated, with some differences in safety profiles across different patient populations. The study found higher rates of specific side effects, such as herpes zoster and skin cancer, in patients with rheumatoid arthritis and psoriatic arthritis. However, the rates of more severe events, such as infections and cardiovascular events, were generally low across all patient populations. The study provides valuable information for healthcare professionals and patients considering upadacitinib treatment.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.