CenTrial Logo

New Vaccine for Chickenpox Shows Positive Results in Clinical Trial


Clinical trial finds new chickenpox vaccine safe and effective

Chickenpox is a highly contagious disease caused by the varicella-zoster virus. The most effective way to prevent chickenpox is through vaccination. Currently, there is a vaccine called vOka that is used to prevent chickenpox. However, there have been concerns about the safety of this vaccine.

To address these concerns, researchers have developed a vaccine candidate called v7D. They conducted a clinical trial to test the safety and effectiveness of this vaccine candidate. The trial involved 224 healthy participants aged 1–49 years who had not previously been vaccinated for chickenpox or had the disease.

Clinical Trial

The trial was randomized, double-blind, and placebo-controlled. This means that the participants were randomly assigned to receive one of three doses of v7D, the existing vOka vaccine, or a placebo. Neither the participants nor the researchers knew who received which treatment, and some participants received a placebo which means they did not receive any vaccine. This helped to ensure that the results were unbiased.

The primary goal of the trial was to determine the safety of the vaccine, while the secondary goal was to assess its effectiveness. The researchers monitored the participants for any adverse reactions for 42 days after vaccination. Adverse reactions can include things like fever, rash, or pain at the injection site. They also monitored the participants for any serious adverse events for six months after vaccination. Serious adverse events are things like hospitalization or death that are potentially related to the vaccine.


The researchers found that the incidence of adverse reactions within 42 days post-vaccination was similar among the v7D groups, vOka group, and placebo group. In other words, the people who received the v7D vaccine did not experience more adverse reactions than those who received the vOka vaccine or the placebo. No serious adverse events were found to be related to the vaccine.

Are you interested in clinical trials near you?

You can receive free notification of a trial for this, or any other condition, by completing a short confidential health profile.
Find a clinical trial near me

The researchers also evaluated the effectiveness of the vaccine by measuring the immune response of the participants. They found that all of the children aged 1–12 years who received the v7D vaccine developed antibodies against the varicella-zoster virus.

Antibodies are proteins produced by the immune system that help to fight off infections. In the group of participants aged 1–49 years who received the v7D vaccine, the immune response was similar to that of the vOka vaccine group and significantly higher than that of the placebo group.

Overall, the researchers concluded that the v7D vaccine was safe and effective. The results of this study provide promising evidence that v7D may be a safer alternative to the existing vOka vaccine. However, further studies are needed to confirm these findings and to determine whether v7D is effective in preventing chickenpox in larger populations.


The clinical trial of the v7D vaccine candidate provides encouraging results for the prevention of chickenpox. The vaccine appears to be safe and effective in providing an immune response against the varicella-zoster virus. Further research is needed to confirm these findings and to determine whether v7D is a viable option for routine vaccination programs. In the meantime, the current vaccine options should still be considered by individuals and healthcare providers as the best way to prevent chickenpox.


THE LANCET, Feb-18-23

Share this article with a friend:

Get emailed clinical trial results in the categories of your choice:
Free subscription to clinical trial results

Signup to be notified of clinical trials near you that match your condition

Signup and be matched to trials near you
This free service will notify you of current and future clinical trial matches.

This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.