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Grape Skin Extract Could Be an Effective Treatment for Dry Eye Disease


Clinical trial shows grape skin extract is an effective treatment for dry eye

Dry eye disease, also known as keratoconjunctivitis sicca or simply dry eye, is a common eye condition that occurs when the eyes do not produce enough tears or the tears evaporate too quickly. Tears are essential to maintain the health of the eye's surface and provide clear vision. They contain a mixture of water, oils, and mucus that lubricates and protects the eyes from infection.

When there is not enough moisture in the eyes, people with dry eye disease may experience a range of symptoms such as stinging, burning, redness, itching, blurred vision, and sensitivity to light. They may also feel like something is in their eye or have trouble wearing contact lenses.

Mild cases can often be managed with over-the-counter artificial tears, or prescription eye drops that increase tear production or reduce inflammation. A study has investigated using anthocyanin oligomers isolated from grape skin extract to treat dry eye disease. Anthocyanin oligomers are a natural compound in grapes, berries, and other fruits. They have antioxidant and anti-inflammatory properties.

The study involved 108 patients with dry eye disease who were randomly divided into a placebo group and a treatment group. The placebo group received maltodextrin, while the treatment group received anthocyanin oligomers. The clinical efficacy, clinical indices, and occurrence of adverse reactions were compared between the two groups.

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The results showed that anthocyanin oligomers were safe and effective in treating mild-to-moderate dry eye disease. The treatment group improved tear break-up time, intraocular pressure, ocular surface disease, and patient symptomatology. The study concluded that oral anthocyanin oligomers could be a viable option for treating dry eye disease, as it enhances the therapeutic effect and improves patients' quality of life while ensuring treatment safety.

This study provides promising results for using grape skin extract as a treatment option for dry eye disease, which could benefit many people who suffer from this condition.


In conclusion, dry eye disease is a common ocular condition that affects many people. This study proves that grape skin extract, specifically anthocyanin oligomers, could be an effective and safe treatment option for mild-to-moderate dry eye disease. Further research is needed to fully understand this treatment option's mechanism of action and potential side effects. Still, it provides a promising avenue for improving the quality of life of dry eye disease patients.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.