CenTrial Logo

Probiotics for Anxiety, Insomnia, and Sleep Deprivation in Students With Test Anxiety


Clinical trial determines that a probiotic is beneficial to students with test anxiety

Test anxiety is a common issue among students facing exams. Worry, fear, or unease can make students nervous before a test. This anxiety can affect their performance and well-being. Symptoms may include a racing heart, sweaty palms, or trouble concentrating. It's crucial to understand that some stress level is normal and can even motivate one to study.

However, when test anxiety becomes overwhelming, it can lead to problems. Techniques like deep breathing, staying organized, and practicing relaxation can help manage test anxiety. Seeking support from teachers or counselors is also essential to perform well in exams.

Clinical Trial

A clinical trial investigated whether a probiotic called Lactobacillus plantarum JYLP-326 can make a difference for students with test anxiety. Sixty anxious students enrolled in the study and were divided into two groups: one got a placebo (a fake treatment), and the other got the probiotic JYLP-326. Both groups took their products twice a day for three weeks. A third group of thirty calm students didn't get any treatment. The researchers used questionnaires to check how the students felt at the start and end of the study. Researchers analyzed their gut bacteria and stool chemicals using 16S rRNA sequencing and untargeted metabolomics.


The questionnaires showed that the students who took JYLP-326 felt better. Their anxiety, depression, and sleep problems improved. The students in the placebo group had more diverse gut bacteria than the calm students. They had more of some bacteria like Bacteroides and Roseburia but less of others like Prevotella and Bifidobacterium. However, the students who took JYLP-326 had a better balance in their gut bacteria, similar to students without test anxiety.

Are you interested in clinical trials near you?

You can receive free notification of a trial for this, or any other condition, by completing a short confidential health profile.
Find a clinical trial near me
Students with test anxiety had elevated Ethyl sulfate levels and too little Cyclohexylamine in stool. However, after taking JYLP-326, these were normalized.


This study suggests that taking L. plantarum JYLP-326 could help college students with test anxiety. It made them less anxious, less depressed, and sleep better. This probiotic works by fixing their gut bacteria and stool chemicals. Students with test anxiety may benefit from probiotics, an effective alternative to medication or therapy. However, more research is needed to confirm these findings and understand how the probiotic helps.

Share this article with a friend:

Get emailed clinical trial results in the categories of your choice:
Free subscription to clinical trial results

20,000 clinical trials are seeking participants.
Signup and be matched to trials near you
This free service will notify you of current and future clinical trial matches.

This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.