CenTrial Logo

Can Celery Seed Extract affect Hypertension and Anxiety?


Clinical trial reveals that celery seed extract is beneficial for hypertension and anxiety

Anxiety and depression are significant public health concerns that can lead to increased hospitalizations and mortality rates. These mental health conditions can also exacerbate hypertension and vice versa.

Clinical Trial

A clinical trial examined the effects of celery seed extract, containing the active ingredient 3-n-butylphthalide, as a drug supplement on anxiety and secondary depression in hypertensive patients. The trial lasted for four weeks, with a 4-week washout period. Fifty hypertensive patients received a placebo or celery seed extract capsules (1.34 g per day) to supplement their medication for four weeks. Blood pressure parameters were measured using a 24-hour ambulatory blood pressure monitoring device. Anxiety and depression and their various symptoms were evaluated using the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI).


During the celery treatment phase, there was a significant reduction in BAI and BDI scores. Symptoms of anxiety, such as inability to relax, nervousness, numbness, dizziness, flushed face, sweating, and breathing difficulties, significantly improved with celery consumption. Celery also demonstrated the ability to alleviate symptoms of depression, including sadness, crying, loss of energy, insomnia, irritability, fatigue, loss of interest in sex, and feelings of punishment. Additionally, celery therapy resulted in a significant reduction in blood pressure parameters.

Are you interested in clinical trials near you?

You can receive free notification of a trial for this, or any other condition, by completing a short confidential health profile.
Find a clinical trial near me


This study explored the psychometric properties of anxiety and depression, and the findings were promising. Celery seed extract exhibited anti-anxiety and anti-depressive properties when used as a supplement in hypertensive patients. Celery seed extract may be a beneficial adjunct treatment for anxiety, depression, and hypertension.

Share this article with a friend:

Get emailed clinical trial results in the categories of your choice:
Free subscription to clinical trial results

Whether you're healthy or have a medical condition you can participate in a clinical trial.
Signup and be matched to trials near you
This free service will notify you of current and future clinical trial matches.

This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.