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Have You Tested Positive for COVID-19 in the Last 10 Days?

IRB Approved As Modified
at the Study Level
Oct 15, 2023

ACTIV-6 clinical trial

What is Activ-6?

It is part of HIH Accelerating COVID-19 Therapeutic interventions and Vaccines (ACTIV) program.

ACTIV-6 is testing medictions that are already approved for other diseases to learn if they can help people with mild-to-moderate COVID-19 feel better faster and stay out of the hospital.


Funded by NIH, operated by Duke Clinical Research Institute

Study Site:

Jadestone Clinical Research, LLC

Study doctor:

Jonathan Cohen, MD, FACP

Who can participate:

  • At least 30 years old
  • Test positive for COVID-19 within the past 10 days
  • At least 2 COVID-19 symptoms within 7 days

Study medication:


What will you do if you decide to participate:

  • The study medication and an oximeter will be shipped to you at no cost.
  • Take the study medication (Metformin or placebo) for 14 days.
  • Complete online surveys. No office visits needed.
  • You can take other standard of care medication at the same time.


up to $125

Complete the intake form below to be contacted within 48 hours.