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Efficacy of Modified Lifespan Integration for PTSD after Sexual Assault


Clinical trial shows one session of Modified Lifespan Integration is effective in treating females with PTSD resulting from a single sexual assault

PTSD, or Post-Traumatic Stress Disorder, can happen after a traumatic event like sexual assault. It causes ongoing problems like intrusive memories, avoiding reminders, feeling on edge, and negative thoughts and emotions. Talking to a mental health professional to help process the painful memories is important. Medication and support groups can also be helpful. Activities like exercise and mindfulness are important for recovery, which takes time, but it's possible to heal and move forward from the trauma with support.

Clinical Trial

The efficacy of a one-session treatment called Modified Lifespan Integration (MLI) was tested for individuals with post-traumatic stress disorder (PTSD) after experiencing one sexual assault. The investigators aimed to examine the reduction of PTSD symptoms through a modified perspective on treatment.

The research followed a single-center, individually randomized waitlist-controlled design, with participants allocated in a 1:1 ratio. The intervention consisted of one session lasting 90 to 140 minutes and a post-treatment follow-up at 3 weeks. Only females, with an average age of 24, experienced one sexual assault within the past 5 years and met specific criteria were included in the study.

The primary outcome was the difference in mean PTSD symptoms, as measured by the Impact of Event Scale-Revised (IES-R), between the two trial arms at the follow-up time point. Of the 135 interested participants, 38 were ultimately included, with 36 completing baseline measures and included in the intent-to-treat analyses. Additionally, 33 participants were analyzed per protocol.

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In the intervention arm, 72% of participants no longer met the criteria for PTSD in the per-protocol analysis, compared to only 6% in the waiting list arm. The IES-R scores in the intervention arm were significantly reduced by half on average, while the waiting list arm showed minimal changes in symptoms. Notably, no adverse effects or drop-outs were observed during the study.



The findings suggest that one session of Modified Lifespan Integration is an effective treatment for females aged 15 to 65 with PTSD resulting from a single sexual assault. With a low drop-out rate and promising outcomes, MLI could be considered a valuable treatment option for this population in clinical settings. It is important to replicate these results in future studies to confirm the effectiveness of MLI and provide further support for its implementation in treating PTSD resulting from sexual abuse. Accessible, acceptable, and affordable treatments for PTSD after sexual abuse are vital in addressing the significant health consequences of this traumatic experience.
ClinicalTrials.gov NCT03141047

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.