Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is a difficult condition that causes a lot of symptoms and tends to come back even after treatment. However, a clinical trial has found a potential solution that shows promise in managing ECRSwNP: steroid-eluting stents. A clinical trial studied the effectiveness and safety of these stents in treating ECRSwNP.
The Clinical Trial
In the trial, researchers enrolled 98 patients aged 18 to 65 who had ECRSwNP and needed surgery. At the end of the surgery, they randomly placed absorbable steroid-eluting stents in one sinus of each patient. The researchers wanted to see how well the stents worked, so they measured different things like nasal symptoms, nasal resistance, and eosinophil counts in the ethmoid mucosa.
Results and Findings
Ninety-five patients completed the trial, and the results provided important insights into the effectiveness of steroid-eluting stents. The researchers found that the stents led to significant improvements in various aspects of the condition.
They saw that the patients who had the stent had lower scores on the Lund-Kennedy endoscopic scale at 4, 8, and 12 weeks after the surgery. This means that their sinuses were in better condition compared to the patients who did not have the stent. The control side (without the stent) showed more tissue inflammation at week 4 and higher scores for volumetric measurements, nasal obstruction, and overall nasal symptoms at week 8. These results suggest that the stents can help reduce inflammation and improve symptoms.