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Zavegepant Nasal Spray: A Promising Option for Migraine


Clinical trial determines that zavegepant nasal spray is an effective treatment for migraine

Migraines are a common and debilitating condition that affects millions of people worldwide. Fortunately, researchers are constantly working to develop new treatments to help those who suffer from this condition. A nasal spray has been introduced as a potential remedy for acute migraine attacks.

A migraine is a headache that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. It's often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. Migraine attacks can last for hours to days, and the pain can be so severe that it interferes with your daily activities.

Calcitonin gene-related peptide-targeting agents are a novel class of therapeutics for migraine, but none are currently available as a nonoral option for acute treatment. Zavegepant nasal spray is a third-generation calcitonin gene-related peptide (CGRP) receptor antagonist. It is the first CGRP available for nasal administration. However, strong clinical data on its safety and efficacy is deficient.

Clinical Trial

A clinical trial evaluated the tolerability and effectiveness of zavegepant nasal spray for the treatment of acute migraine episodes.

The trial involved 1,588 adults who presented with an acute episode of migraine. The researchers divided the participants into four groups. Three groups received different doses of zavegepant nasal spray (5mg, 10mg, and 20mg), while the fourth group received a placebo nasal spray that looked and tasted like the real thing but contained no active ingredients.

The participants were instructed to use the nasal spray when they were experiencing a migraine attack. They were then asked to rate their pain level after using the spray. The researchers also measured other factors, such as the freedom from the most bothersome symptom at 2h postdose.

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The results of the clinical trial were very positive. The participants who received zavegepant nasal spray doses of 10mg and 20mg experienced significantly less pain compared to those who received the placebo nasal spray. 22.5% of patients in the 10mg group and 23.1% of patients in the 20mg group experienced pain relief compared to 15.5% of patients in the placebo group. However, the 5mg zavegepant dose did not result in any meaningful beneficial effect.

Furthermore, the zavegepant nasal spray was well-tolerated by the participants. Side effects were generally mild and transient, meaning they went away on their own without any intervention. The most common side effects were dysgeusia, nausea, and nasal discomfort.

So what does all of this mean for people who suffer from migraines? Well, it means that there may be a new and effective treatment option available.


Migraines are a painful and disruptive condition that can greatly impact a person's quality of life. However, the results of this clinical trial suggest that zavegepant nasal sprays of 10mg and 20mg may be effective treatment options for those who suffer from migraines. These results are certainly encouraging and offer hope to those who struggle with migraines on a regular basis.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.