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Neurostimulation may be a Potential Treatment Option for Migraine


Clinical trial finds that neurostimulation provides relief to migraine sufferers

Migraines affect millions of people worldwide. Currently, there is no cure for this disease, however, there are medications with which the symptoms can be managed.

Migraine is a type of headache characterized by recurrent attacks of moderate to severe throbbing and pulsating pain on one side of the head. In addition to pain, it can also cause nausea, vomiting, and increased sensitivity to sound and light.

There are several pharmacologic options available for the management of migraine. Additionally, non-invasive neuromodulation devices stimulating a single peripheral nerve or anatomic distribution are routinely used by patients with migraine refractory to the first-line drugs. Concurrent occipital and trigeminal stimulation has previously been used for migraines in invasive settings but clinical data on its external (non-invasive) use in migraine is limited.

Clinical Trial

A clinical trial has shown promising results for this type of migraine treatment called external concurrent occipital and trigeminal neurostimulation.

The treatment involves using a device that sends electrical impulses to the nerves in the back of the head (occipital nerves) and the face (trigeminal nerves). The idea behind the treatment is that the electrical stimulation can disrupt the pain signals that are being sent to the brain, which can reduce or eliminate the pain of a migraine.

The clinical trial involved 109 patients who had a diagnosis of migraine with or without aura. They were randomly assigned to two groups. One group received the concurrent neurostimulation while the other group did not (they received a placebo treatment that looked and felt like the real treatment but did not actually provide any electrical stimulation).

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The researchers found that the group that received the neurostimulation treatment had a significant reduction in the frequency and severity of their migraines. 60% of participants (30/50) in the treatment arm reported pain relief at 2 h after initiation of the first treatment (primary outcome) compared to 37% (22/59) in the control arm.

The trial also found that the neurostimulation treatment was safe and well-tolerated by participants. There were no serious adverse events reported.


The results of this clinical trial suggest that external concurrent occipital and trigeminal neurostimulation may be an effective and safe treatment option for people who suffer from migraines. The treatment is non-invasive and can be done using a portable device. It may be particularly useful for people who do not respond to other migraine treatments or who experience significant side effects from medication.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.