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Clinical Trial Examines Strategies for Improving Testosterone Level in Obese Men


Clinical trial compares four treatments for low testosterone levels in obese men

Obesity is a common health problem worldwide, often leading to other medical conditions. Men with obesity also tend to have low levels of testosterone, which may further complicate their health. A clinical trial aimed to evaluate the effect of potential therapeutic strategies for low testosterone in men with obesity.

The study recruited 106 men aged 18 to 50 with obesity, low levels of testosterone, and no diabetes mellitus. The men were divided into four groups: placebo, metformin, testosterone, and a combination of metformin and testosterone. The trial was conducted for a year and was randomized, double-blind, and placebo controlled.

The study's primary outcome was the change in insulin resistance measured by the Homeostasis Model Assessment for Insulin Resistance index. The secondary outcomes included changes in testosterone levels, body composition, metabolic variables, erectile function, and health-related quality of life (HRQoL).

The study found that all active groups (metformin, testosterone, and combination therapy) significantly reduced insulin resistance compared to the placebo group. However, combination therapy was not superior to testosterone alone in decreasing insulin resistance. Moreover, there was no evidence of the additive benefit of using metformin and testosterone.

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Interestingly, the combination of metformin plus testosterone significantly increased total and free testosterone concentrations compared to the placebo. However, no significant changes were observed in body composition, metabolic variables, erectile function, or HRQoL with any treatment.

Overall, the study suggests that among men with obesity and low testosterone concentrations, all treatment regimens reduced insulin resistance compared to placebo. There was no significant additive benefit from combining metformin and testosterone except for an increase in total and free testosterone levels. Therefore, future studies may be necessary to identify the most effective treatment for low testosterone and insulin resistance in men with obesity.
Metabolism, Aug-18-22

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.