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New Study Supports Anifrolumab as a Long-Term Treatment Option for Lupus


Anifrolumab proven to be effective for Lupus in clinial trial

Systemic lupus erythematosus (SLE), often referred to as lupus, is a chronic autoimmune disease. This means that the body's immune system, which is designed to fight off viruses, bacteria, and other harmful invaders, attacks healthy tissues and organs in the body. SLE can affect multiple parts of the body, including the skin, joints, kidneys, heart, lungs, and brain. Symptoms of SLE include joint pain, skin rashes, fever, fatigue, and cognitive dysfunction.

While there is no cure for SLE, there are various treatments available to help manage symptoms and reduce the risk of complications. Anifrolumab is a medication used to treat SLE. It works by blocking a type of protein called interferon, which plays a role in the immune system's response that can cause damage in people with SLE. By blocking this protein, anifrolumab can reduce inflammation and improve symptoms of SLE. It is usually reserved for people with moderate-to-severe SLE who have not responded to other treatments.

In a recent phase 3 trial, researchers tested the safety and tolerability of anifrolumab over a period of three years. Participants who had completed an earlier clinical trial for SLE were enrolled in the study and were randomly assigned to receive either anifrolumab or a placebo. A placebo is a treatment or substance that looks and feels like a real medical treatment but does not actually contain any active ingredients.

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The study found that anifrolumab was generally safe and well-tolerated by patients with SLE. Patients who received anifrolumab had lower rates of serious adverse events and fewer infections compared to those who received a placebo. Patients who received anifrolumab also had lower cumulative glucocorticoid use and greater improvement in their SLE disease activity.

The study did find that patients who received anifrolumab had higher rates of COVID-related adverse events, including asymptomatic infections. However, no COVID-related adverse events occurred in patients who had been fully vaccinated.

Overall, the study concluded that anifrolumab is a safe and effective treatment option for patients with moderate-to-severe SLE who are receiving standard therapy.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.