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N-Acetylcysteine Shows Positive Effects for Lupus Patients in Clinical Trial


Clinical trial finds N-Acetylcysteine effective for lupus patients

Systemic lupus erythematosus (SLE) is a disease where the immune system mistakenly attacks healthy tissues and organs, causing inflammation and damage. While there's no cure for SLE, research has discovered a potential treatment option called N-acetylcysteine (NAC).

Clinical Trial

A clinical trial was conducted on 80 SLE patients, who were divided into two groups. One group received NAC, while the other group received regular treatments. The trial was randomized and double-blind, which means that neither the patients nor the researchers knew which group each patient was in, to prevent bias.

The patients were evaluated before and after the trial using two scoring systems called the British Isles Lupus Assessment Group (BILAG) and the SLE Disease Activity Index (SLEDAI). These scoring systems measure the severity of SLE symptoms and organ involvement. Blood tests were also taken to evaluate the levels of inflammation and other markers in the body.


After three months, the group that received NAC had a statistically significant decrease in their BILAG and SLEDAI scores compared to the control group. This means that NAC helped to improve their disease activity and reduce organ damage. Specifically, the NAC group showed significant improvements in their mucocutaneous, neurological, musculoskeletal, cardiorespiratory, renal, and vascular complications.

Additionally, the trial found that NAC helped to increase the level of CH50 in the blood. CH50 is a measure of the complement system, which is a group of proteins that help the immune system fight off infections. A low CH50 level is associated with an increased risk of infections, and the NAC group showed an improvement in this marker.

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One important aspect of the trial was that there were no reported side effects from the use of NAC. This is encouraging news for those who are seeking new treatment options for SLE, as many current treatments have unwanted side effects.

It's important to note that this was a small trial, and more research is needed to confirm these results. However, these findings are promising and suggest that NAC could be a valuable addition to current SLE treatments.

If you have SLE, it's important to talk to your doctor before trying any new treatment options. Every person's body is different, and what works for one person may not work for another. However, NAC could be an option worth discussing with your doctor, especially if you're experiencing SLE symptoms that are not adequately managed with current treatments.


This clinical trial showed that N-acetylcysteine (NAC) could be a valuable addition to current lupus treatments. The trial found that NAC helped to decrease disease activity, improve organ involvement, and increase the complement system's level without causing any side effects. While more research is needed to confirm these findings, this trial provides hope for those who suffer from SLE and highlights the potential of NAC as a new treatment option.


BMC, Feb-21-23


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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.