Systemic lupus erythematosus (SLE) is a condition where the body's immune system mistakenly attacks healthy tissues and organs. This can cause pain, swelling, and damage to different parts of the body such as the skin, joints, and kidneys. Unfortunately, there are limited treatment options available for people with SLE, so researchers are constantly looking for new therapies to help patients manage their symptoms.
One potential treatment for SLE is a drug called Baricitinib. Baricitinib works by inhibiting a group of enzymes called Janus kinases that are involved in the immune response. In a clinical trial, Baricitinib was shown to have some therapeutic benefits in patients with SLE. The trial involved SLE patients who received either Baricitinib or a placebo. The researchers looked at changes in levels of specific markers in the blood, such as anti-dsDNA and IgG, which are used to measure disease activity.
The researchers found that Baricitinib treatment resulted in a significant decrease in the levels of anti-dsDNA antibodies in patients who had elevated levels at the beginning of the study. This decrease was observed starting at week 2 for the 2mg dose of Baricitinib, and at week 4 for the 4mg dose. The decrease continued throughout the 24-week study period. In contrast, patients who received a placebo did not show a significant decrease in anti-dsDNA levels.