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Can pomegranate Extract Improve Liver Health in Non-Alcoholic Fatty Liver Disease?


Clinical trial finds that pomegranate extract is effective in treating non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder that affects people who don't drink too much alcohol. NAFLD is usually caused by obesity, insulin resistance, and a sedentary lifestyle. NAFLD can lead to liver damage and even liver failure if not treated properly. Researchers have been trialing the potential benefits of pomegranate extract in treating NAFLD. In this article, we will discuss the findings of a clinical trial that evaluated the effect of pomegranate extract on NAFLD.

Clinical Trial

The trial involved 44 patients with NAFLD. The participants were divided into two groups: one group was given pomegranate extract tablets, while the other group was given a placebo. The intervention period was 12 weeks, and at the beginning and end of the trial, the participant's blood was drawn to check for various markers of liver health.


The results of the trial showed that the group that received pomegranate extract experienced a significant reduction in the levels of several liver enzymes. These enzymes are usually elevated in people with NAFLD, and their reduction indicates improved liver function.


In addition, pomegranate extract also led to a decrease in two proteins called fetuin-A and fibroblast growth factor 21 (FGF-21). These proteins are associated with liver damage and inflammation, and their decrease suggests that pomegranate extract has anti-inflammatory properties that can protect the liver.


Furthermore, pomegranate extract was found to reduce interleukin-6 (IL-6), a marker of inflammation that is elevated in people with NAFLD. By reducing IL-6, pomegranate extract can help improve insulin sensitivity and prevent the progression of NAFLD.


Finally, the trial found that pomegranate extract led to an increase in total antioxidant capacity. This is important because NAFLD is associated with oxidative stress, which occurs when there is an imbalance between antioxidants and free radicals in the body. By increasing the body's total antioxidant capacity, pomegranate extract can protect the liver from oxidative stress and prevent further damage.


The findings of this clinical trial suggest that pomegranate extract can be an effective supplement for treating NAFLD. It reduces several markers of liver damage and inflammation, improves insulin sensitivity, and increases the body's total antioxidant capacity. Pomegranate extract is a safe and natural alternative to conventional medications for NAFLD, and it can be easily incorporated into the diet as a functional food or taken in supplement form.

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If you have NAFLD or are concerned about your liver health, it is important to talk to your doctor before trying any supplements. Your doctor can help you determine the best course of treatment based on your individual needs and medical history.


Eating a healthy diet and exercising regularly can also help improve liver health and prevent NAFLD. It is important to maintain a healthy weight and avoid consuming too much sugar, fried foods, and processed foods. By making these lifestyle changes and incorporating pomegranate extract into your diet, you can improve your liver health and reduce your risk of NAFLD.


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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.