Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder that affects people who don't drink too much alcohol. NAFLD is usually caused by obesity, insulin resistance, and a sedentary lifestyle. NAFLD can lead to liver damage and even liver failure if not treated properly. Researchers have been trialing the potential benefits of pomegranate extract in treating NAFLD. In this article, we will discuss the findings of a clinical trial that evaluated the effect of pomegranate extract on NAFLD.
Clinical Trial
The trial involved 44 patients with NAFLD. The participants were divided into two groups: one group was given pomegranate extract tablets, while the other group was given a placebo. The intervention period was 12 weeks, and at the beginning and end of the trial, the participant's blood was drawn to check for various markers of liver health.
Results
The results of the trial showed that the group that received pomegranate extract experienced a significant reduction in the levels of several liver enzymes. These enzymes are usually elevated in people with NAFLD, and their reduction indicates improved liver function.
In addition, pomegranate extract also led to a decrease in two proteins called fetuin-A and fibroblast growth factor 21 (FGF-21). These proteins are associated with liver damage and inflammation, and their decrease suggests that pomegranate extract has anti-inflammatory properties that can protect the liver.
Furthermore, pomegranate extract was found to reduce interleukin-6 (IL-6), a marker of inflammation that is elevated in people with NAFLD. By reducing IL-6, pomegranate extract can help improve insulin sensitivity and prevent the progression of NAFLD.
Finally, the trial found that pomegranate extract led to an increase in total antioxidant capacity. This is important because NAFLD is associated with oxidative stress, which occurs when there is an imbalance between antioxidants and free radicals in the body. By increasing the body's total antioxidant capacity, pomegranate extract can protect the liver from oxidative stress and prevent further damage.
Conclusion
The findings of this clinical trial suggest that pomegranate extract can be an effective supplement for treating NAFLD. It reduces several markers of liver damage and inflammation, improves insulin sensitivity, and increases the body's total antioxidant capacity. Pomegranate extract is a safe and natural alternative to conventional medications for NAFLD, and it can be easily incorporated into the diet as a functional food or taken in supplement form.