Adverse reactions to drugs refer to unexpected or harmful effects that occur as a result of taking medications. These reactions can range from mild discomfort to severe and life-threatening conditions. Common adverse reactions include allergic reactions, such as skin rashes or hives, gastrointestinal disturbances, dizziness, headaches, and changes in blood pressure.
Severe adverse reactions may involve organ damage, blood disorders, or anaphylaxis. Factors contributing to adverse reactions include individual susceptibility, drug interactions, improper dosage, or underlying medical conditions. Prompt identification and reporting of adverse reactions are crucial for ensuring patient safety and optimizing healthcare interventions. Healthcare professionals play a vital role in monitoring and managing adverse reactions to drugs.
Clinical TrialPharmacogenetic testing involves analyzing a person's genetics to determine their response to certain drugs and has proven beneficial for specific gene-drug combinations. However, the effectiveness of using a comprehensive pharmacogenetic panel as a pre-emptive genotyping strategy has yet to be thoroughly evaluated.
A trial was conducted across multiple European countries, including Austria, Greece, Italy, the Netherlands, Slovenia, Spain, and the UK. The study involved 18 hospitals, nine community health centers, and 28 pharmacies. Eligible participants were 18 or older and received their first prescription for a drug recommended by the Dutch Pharmacogenetics Working Group.
Patients with prior genetic testing for genes relevant to the prescribed medication, those with a treatment duration of less than seven consecutive days, and individuals with severe renal or liver insufficiency were excluded. Written informed consent was obtained from all participants.