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How effective are Microstents in the Treatment of Glaucoma?


Clinical trial concludes that microstents in combination with cataract surgery are beneficial for glaucoma patients

A clinical trial explored the efficacy of Schlemm canal microstents, also called Hydrus microstent, together with Phacoemulsification in Open-Angle Glaucoma. 

Glaucoma is a leading cause of blindness in old people worldwide. It is a condition that can cause irreversible vision loss and blindness if left untreated. It's a disease that affects the optic nerve, which is the nerve that sends visual information from the eye to the brain. It is characterized by a build-up of fluid in the front part of the eye resulting in increased pressure in the eye. There are different types of glaucoma, but the most common form is called open-angle glaucoma. It progresses gradually, where the eye does not drain fluid as well as it should (like a clogged drain). As a result, eye pressure builds and starts to damage the optic nerve.

Fortunately, there are treatments available for glaucoma, including medications and surgery. One surgical treatment that has been gaining attention in recent years is the Schlemm canal micro stent, also known as the Hydrus microstent. This is a tiny device that is implanted in the eye to help improve the flow of fluid out of the eye, which can reduce intraocular pressure and prevent further damage to the optic nerve. However, long-term clinical data on its efficacy has been deficient.

Clinical Trial

A group of researchers conducted a clinical trial to evaluate the safety and effectiveness of the Hydrus microstent in combination with cataract surgery for the treatment of open-angle glaucoma. The trial followed patients for three years after the procedure to assess the long-term outcomes.

It included 106 patients with open-angle glaucoma who underwent cataract surgery along with the Hydrus microstent implantation. The researchers evaluated various factors, including intraocular pressure, increased medication use, glaucoma re-operation, and laser surgery at multiple time points over the three-year period.

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The results of the clinical trial showed that the glaucoma re-operation rate was 86%, the rate of laser therapy was 83%, and intra-occular pressure was raised in 91% of the patients.

The results of this clinical study are very encouraging. The researchers found that the Hydrus microstent implantation led to a significant reduction in intraocular pressure (26.5%) that was sustained over the three-year follow-up period. The reduction in intraocular pressure was also achieved with a decrease in the number of glaucoma medications required by the patients.


Overall, the trial provides strong evidence that the Schlemm canal microstent (Hydrus microstent) can be a highly effective treatment for open-angle glaucoma when used in combination with cataract surgery. The long-term outcomes of the clinical trial demonstrate that the reduction in intraocular pressure achieved by the Hydrus microstent implantation is sustained over time and leads to a decrease in the need for glaucoma medications.


The results of this clinical trial provide valuable information for both eye doctors and patients with open-angle glaucoma. The Hydrus microstent implantation, when used in combination with cataract surgery, can be a safe and effective treatment option for reducing intraocular pressure and improving clinical outcomes in glaucoma patients.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.