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Comparing Autologous Fibrin Glue with Traditional Sutures for Pterygium Surgery


Clinical trial compares fibrin glue with sutures for pterygium eye surgery

Pterygium is a common eye disorder that occurs when a growth of tissue develops on the conjunctiva, which is the clear tissue that covers the white part of the eye. Pterygium can cause redness, irritation, and sometimes vision problems. Surgical removal of the pterygium is often necessary, and conjunctival autologous graft (CAG) is a technique that has been used for many years to repair the area where the pterygium was removed. In this clinical trial, researchers compared two methods of graft attachment: autologous fibrin glue and traditional sutures.

Autologous fibrin glue is a substance that can be prepared from the patient's own blood components. The glue is created by collecting plasma from the patient and enhancing it with calcium gluconate. The resulting mixture can then be used to attach the graft. The traditional method of attachment is through the use of sutures.

Clinical Trial

The study enrolled 61 patients who underwent pterygium surgery with CAG. The patients were randomly assigned to receive either autologous fibrin glue or traditional sutures. The surgical time and postoperative assessments were evaluated on Days 1, 7, 21, 30, and 180. The study measured postoperative edema and pain and assessed the recurrence of the pterygium 6 months after surgery.


The results of the study showed that both techniques were successful in graft adherence, with 83.60% of patients maintaining graft presence at the end of follow-up. However, the autologous fibrin glue had a higher graft loss rate, with 10 patients (10/33) losing their graft in the glue group. Furthermore, only 69.70% of patients in the glue group maintained graft presence in the fourth week, compared to 100% of patients in the suture group. The difference was statistically significant.

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Pain scores were lower in the glue group, but clinical edema was significantly higher. There was no significant difference in graft retraction or the presence of granuloma, necrosis, or postoperative infection between the two groups.

The study concluded that autologous fibrin glue is an affordable option for CAG fixation in contexts where commercial fibrin glue is unavailable. The glue technique could offer some advantages over sutures, such as lower pain scores. However, the study also identified a higher graft loss rate associated with the glue technique. The researchers suggested that the higher rate of graft loss might be related to topical anesthesia and recommended improvements to the technique.


This clinical trial provides evidence that autologous fibrin glue can be used as an alternative to traditional sutures for CAG fixation in pterygium surgery. However, the study also highlights some limitations of the glue technique and the need for further research to optimize the procedure. Overall, the findings of this study could inform the decision-making process for patients and clinicians considering different options for pterygium surgery.


Springer, Jan-18-23

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.