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Can Pistachio Pericarp provide Natural Pain Relief for Knee Osteoarthritis?


Clinical trial concludes pistachio pericarp provides a natural alternative to knee osteoarthritis pain relief

Knee osteoarthritis is a common joint condition that affects millions of people worldwide, especially older adults. It is a degenerative disease that causes the cartilage in the knee joint to break down, leading to pain, stiffness, and decreased mobility. Knee osteoarthritis is often associated with obesity, aging, and previous injuries to the knee joint. While there is no cure for knee osteoarthritis, there are several treatments available to manage the symptoms and slow down the progression of the disease. These treatments include pain medication, physical therapy, weight loss, and surgery in severe cases.

Clinical Trial

A clinical trial has found that pistachio pericarp, the outer layer of the pistachio nut, may help to alleviate the pain. In a clinical trial, the impact of a topical formulation of pistachio pericarp was tested on people with knee osteoarthritis.

The trial involved 75 people who were middle-aged or older and had a body mass index of over 25 kg/m2. They were randomly divided into three groups: one group received piroxicam, which is a common pain medication for osteoarthritis; another group received a topical formulation of pistachio pericarp (TFPP); and the third group received a placebo. The patients applied the treatment twice a day for eight weeks.

The researchers evaluated the patients' knee pain, stiffness, and physical function using two measures: the visual analogue scale and the Western Ontario and McMaster University Osteoarthritis Index. The assessments were made at the beginning of the study, after one month, and after two months.

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The results of the trial showed that the patients who received TFPP had significant improvements in their knee pain, stiffness, and physical function after two months. The improvements were much greater than those in the group that received the placebo. This indicates that pistachio pericarp compounds may be effective in alleviating the symptoms of osteoarthritis.

The researchers also found that TFPP was safe and well-tolerated by the patients. This means that TFPP could be a natural and safe alternative to traditional pain medication for people with osteoarthritis.

If you are interested in trying TFPP, it is important to talk to your doctor first. They can help you determine whether TFPP is a suitable treatment option for you. It is also important to maintain a healthy weight, exercise regularly, and eat a balanced diet to manage osteoarthritis symptoms. By taking a holistic approach, you can help alleviate pain and improve your quality of life.


The clinical trial shows that pistachio pericarp may be an effective and safe alternative to traditional pain medication for people with osteoarthritis. By using TFPP, patients may be able to alleviate their knee pain, stiffness, and physical function. However, more research is needed to confirm these findings and to determine the optimal dosage and duration of treatment. If you are interested in trying TFPP, talk to your doctor to see if it's right for you.


ScienceDirect, Apr-2023



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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.