Knee osteoarthritis is a common joint condition that affects millions of people worldwide, especially older adults. It is a degenerative disease that causes the cartilage in the knee joint to break down, leading to pain, stiffness, and decreased mobility. Knee osteoarthritis is often associated with obesity, aging, and previous injuries to the knee joint. While there is no cure for knee osteoarthritis, there are several treatments available to manage the symptoms and slow down the progression of the disease. These treatments include pain medication, physical therapy, weight loss, and surgery in severe cases.
A clinical trial has found that pistachio pericarp, the outer layer of the pistachio nut, may help to alleviate the pain. In a clinical trial, the impact of a topical formulation of pistachio pericarp was tested on people with knee osteoarthritis.
The trial involved 75 people who were middle-aged or older and had a body mass index of over 25 kg/m2. They were randomly divided into three groups: one group received piroxicam, which is a common pain medication for osteoarthritis; another group received a topical formulation of pistachio pericarp (TFPP); and the third group received a placebo. The patients applied the treatment twice a day for eight weeks.
The researchers evaluated the patients' knee pain, stiffness, and physical function using two measures: the visual analogue scale and the Western Ontario and McMaster University Osteoarthritis Index. The assessments were made at the beginning of the study, after one month, and after two months.