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Breaking the Struggle: The Potential of Genetic Trait Targeting for Weight Loss


New weight loss program targeting genetic traits could be game changer

Are you struggling to lose weight despite following a traditional weight-loss program? A clinical trial suggests that the Regulation of Cues (ROC) weight loss program, which targets genetically determined appetitive traits, could be a viable alternative for adults looking to shed pounds.


The randomized clinical trial involved 271 adults with a body mass index (BMI) of 25 to 45 and no comorbidities that would interfere with participation. Participants were randomly assigned to one of four interventions: ROC, ROC plus behavioral weight loss (ROC+), behavioral weight loss (BWL), or an active comparator (AC). The participants were evaluated over 12 months of treatment and 12 months of follow-up.

The results showed that individuals in the ROC, ROC+, and BWL groups all experienced similar weight loss during treatment and follow-up. However, those with higher levels of food responsiveness lost more weight in the ROC and ROC+ groups than in the BWL or AC groups.

The ROC program is designed to regulate the cues that trigger overeating and weight gain. It specifically targets food responsiveness and satiety responsiveness, which are genetically determined appetitive traits that interact with the environment and can lead to overeating and weight gain. The ROC+ program combines ROC with traditional behavioral weight loss techniques, such as energy restriction, increasing physical activity, and behavior therapy techniques.

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The active comparator group received mindfulness training, social support, and nutrition education. At the end of treatment, the BMI reductions for the ROC, ROC+, and BWL groups were statistically significant and similar. However, the BMI of the AC group was substantially higher.

The findings suggest that the ROC and ROC+ programs could be alternative weight loss programs for adults, particularly those with high food responsiveness levels. These programs may provide a more personalized approach to weight loss by targeting specific appetitive traits.


These results provide hope for those struggling with traditional weight loss programs. If you're having difficulty losing weight, speak to your healthcare provider about whether the ROC or ROC+ program could be right for you.

JAMA, May-18-22
ClinicalTrials.gov NCT02516839

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.