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Chlorthalidone vs. Hydrochlorothiazide: Which Medication is better for High Blood Pressure?

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Clinical trial finds chlorthalidone and hydrochlorothiazide were equally effective in lowering hypertension

High blood pressure, also known as hypertension, is a common health condition that affects many people worldwide. It can increase the risk of heart disease and other cardiovascular problems.

Hypertension
Hypertension is a condition characterized by high pressure of blood in your vessels. World Health Organization defines it as a blood pressure of 140/90 mmHg or higher. An estimated 1.28 billion adults aged 30-79 years worldwide have hypertension and about 46% of adults with hypertension are unaware that they have the condition. Hypertension is a major cause of adverse cardiovascular events such as heart attack, and stroke and can cause premature death. There are several pharmacologic remedies available for the management of hypertension.

Clinical Trial
A clinical trial has compared two commonly prescribed medications for hypertension: chlorthalidone and hydrochlorothiazide in preventing adverse cardiovascular events in hypertensive patients. This article aims to explain the results of the study in simple terms, helping you understand which medication may be more effective in treating high blood pressure.

The trial involved 13,523 participants with hypertension, who were already taking hydrochlorothiazide. These patients were divided into two groups. One group continued to take hydrochlorothiazide while the other group switched to chlorthalidone.

The researchers then observed and analyzed the occurrence of cardiovascular events, such as heart attack, stroke, heart failure, urgent coronary revascularization for unstable angina, and non-cancer-related death among the participants over a certain period of time.

Results
The clinical trial found that chlorthalidone and hydrochlorothiazide were equally effective in reducing hypertension-related adverse cardiovascular events. The adverse cardiovascular events occurred in 702 patients [10.4%] of the chlorthalidone group and 675 patients [10.0%] of the hydrochlorothiazide group. These findings suggest that both medications were equally effective in reducing these cardiovascular side effects.

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Implications
The findings of this clinical trial have important implications for the management of hypertension as they demonstrate that chlorthalidone is not superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension.

Conclusion
The clinical trial comparing chlorthalidone and hydrochlorothiazide for hypertension showed that both medications effectively lowered blood pressure and had similar abilities in reducing the risk of cardiovascular events. This means that if you have high blood pressure and are at risk of heart disease or other cardiovascular problems, chlorthalidone and hydrochlorothiazide may be equally suitable medications for you. It is important to consult with your healthcare provider to determine the best course of treatment for your specific condition, as they can assess your individual needs and guide you in choosing the right medication.
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The New England Journal of Medicine, Dec-29-22
ClinicalTrials.gov 
NCT02185417
About Hypertension
Hypertension Resources




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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.