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Plozasiran Shows Promise for Severe Hypertriglyceridemia


Clinical trial shows plozasiran has promise in reducing high triglyceride levels in patients with severy hypertriglyceridemia

Severe hypertriglyceridemia poses serious health risks, including cardiovascular disease and pancreatitis. Despite available treatments, managing severe hypertriglyceridemia-associated complications remains a challenge. However, clinical trials have shown promising results with an investigational drug called plozasiran.

Clinical Trial

In a randomized clinical trial called SHASTA-2, researchers evaluated the safety and effectiveness of plozasiran in reducing triglyceride levels in patients with severe hypertriglyceridemia. The trial involved 229 participants across multiple centers in different countries.

The results of the trial were remarkable. Patients who received plozasiran experienced significant reductions in triglyceride levels compared to those who received a placebo. These reductions were sustained throughout the trial, with the most significant changes observed at the highest dose of plozasiran.

Key Findings of the trial

  • Triglyceride Reduction: Plozasiran led to a substantial decrease in triglyceride levels, with many patients achieving levels below the threshold associated with acute pancreatitis risk.

  • Improvements in Lipid Parameters: Along with reducing triglycerides, plozasiran also positively impacted other lipid parameters. It led to increases in high-density lipoprotein cholesterol (HDL-C) levels, which are beneficial for heart health. Additionally, there were significant reductions in remnant cholesterol and ApoB48, which are markers of cardiovascular risk.

  • Safety Profile: Importantly, plozasiran demonstrated a generally favorable safety profile. Adverse events were similar between the plozasiran-treated group and the placebo group. Serious adverse events, if any, were mild to moderate and not considered related to the treatment.

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These findings suggest that plozasiran has the potential to be a valuable treatment option for patients with severe hypertriglyceridemia. By effectively lowering triglyceride levels and improving lipid parameters, it could help reduce the risk of cardiovascular disease and pancreatitis in these patients.


While the results are promising, further studies are needed to fully understand the long-term effects of plozasiran and its impact on severe hypertriglyceridemia-associated complications. However, this trial represents a significant step forward in the search for effective therapies for severe hypertriglyceridemia.


The SHASTA-2 trial demonstrates the potential of plozasiran as a breakthrough treatment for severe hypertriglyceridemia. Its ability to safely and effectively reduce triglyceride levels and improve lipid parameters offers hope for better management of this condition in the future. As researchers continue to explore its benefits, plozasiran holds promise in improving the lives of patients with severe hypertriglyceridemia.


JAMA Network, Apr-7-24

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.