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Melatonin Shows Promise in Treating Seizures and Sleep Quality for People with Epilepsy


Clinical trial shows melatonin helps epileptics with seizures and sleep quality

Epilepsy is a neurological disorder characterized by recurrent seizures that can affect people of all ages. It is estimated that about 50 million people worldwide are affected by epilepsy. Seizures can range from mild to severe and can be caused by a variety of factors, including genetic mutations, brain injury, and infections.

Despite advances in diagnosis and treatment, epilepsy remains a challenging condition to manage, and people with epilepsy often face stigma and discrimination. However, with appropriate treatment and support, many people with epilepsy can lead fulfilling lives. Research has focused on developing new treatments to improve seizure control and quality of life for people with epilepsy.

Melatonin is a hormone that helps regulate sleep and wakefulness. A clinical trial looked at how melatonin could help people with epilepsy who were already taking a medicine called valproic acid.

Clinical Trial

The trial included 60 patients who had epilepsy with generalized tonic-clonic seizures, which are a type of seizure that affects the whole body. The patients were given either melatonin or a fake pill called a placebo. They took the medicine for a short time, and then they took a break before trying the other medicine. The goal of the trial was to see if melatonin could make seizures less severe and less frequent, and if it could help people sleep better.


The trial found that when patients took melatonin, their seizures were less severe. They also slept better than when they took the placebo pill. However, melatonin did not seem to make the seizures happen less often, and it did not show any major differences on an electroencephalogram (EEG), which is a test that measures brain activity.

Melatonin is a hormone that our bodies naturally make to help us sleep. You might have heard of it before because it's also sold in stores as a supplement to help people sleep better. Melatonin supplements are safe and have very few side effects.

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The results of this trial are interesting because they show that melatonin could be helpful for people with epilepsy. The patients in this trial were already taking medicine for their seizures, but they still had seizures and trouble sleeping. The addition of melatonin to their treatment made their seizures less severe and helped them sleep better.


This clinical trial suggests that melatonin could be helpful for people with epilepsy who are already taking medicine, especially if they have trouble sleeping. However, more research is needed to figure out exactly how much melatonin people should take and how often they should take it.

This trial is a step forward in finding new ways to treat epilepsy. By adding melatonin to the treatment, the patients had less severe seizures and slept better. Although more research is needed, melatonin could be a helpful addition to the treatment for people with epilepsy.


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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.