CenTrial Logo

Psychobiotics: A Natural and Effective Alternative to Traditional Antidepressants


Clinical trial shows that psychobiotics offer an alternative approach to managing depression

Psychiatric disorders affect millions of people globally, and current treatments are limited in their efficacy. However, a clinical trial suggests that psychobiotics may offer a novel approach to managing depression.

Psychobiotics are a new class of probiotics that act on the gut-brain axis, which is the connection between the gut and the brain. Bifidobacterium breve CCFM1025 is one such probiotic that has been shown to have an antidepressant-like effect in mice. In this study, researchers aimed to assess the potential of this probiotic strain in managing major depression disorder (MDD) in humans and to understand the underlying mechanisms.

Clinical trial

The study involved 45 patients diagnosed with MDD who were randomly assigned to either the placebo or probiotic groups. Patients in the probiotic group were given a dose of viable bacteria daily for four weeks, while those in the placebo group were given maltodextrin.

Changes in psychometric and gastrointestinal symptoms were evaluated using various scales, and serum measures were determined, including cortisol, TNF-α, and IL-β. The researchers also investigated serotonin turnover in the circulation, gut microbiome composition, and tryptophan metabolites to clarify the probiotic's mechanisms of action.

The results showed that the probiotic had a better antidepressant-like effect than the placebo, based on evaluations using the Hamilton Depression Rating scale-24 Items and the Montgomery-Asberg Depression Rating Scale. The researchers found that emotional and gastrointestinal problems may be affected by the serotonergic system, and the probiotic could significantly reduce serum serotonin turnover compared to the placebo.

Are you interested in clinical trials near you?

You can receive free notification of a trial for this, or any other condition, by completing a short confidential health profile.
Find a clinical trial near me

The study suggests that the psychobiotic strain B. breve CCFM1025 is a promising candidate for managing depression and associated gastrointestinal disorders. The mechanisms of action may be related to changes in the gut microbiome and tryptophan metabolism. These findings support the future clinical applications of psychobiotics in the treatment of psychiatric disorders.

This study provides hope for a new treatment approach for those suffering from depression. Psychobiotics offer a natural and potentially more effective alternative to traditional antidepressant medications. The gut-brain axis is a relatively new area of research, and as scientists continue to explore its potential, we may see new and innovative treatments for psychiatric disorders in the future. 


The study provides evidence that B. breve CCFM1025 has an antidepressant-like effect and could be a promising candidate for managing depression and associated gastrointestinal disorders. The probiotic strain's mechanisms of action may be related to changes in the gut microbiome and tryptophan metabolism. These findings offer hope for those struggling with depression and provide a novel approach to managing this debilitating condition.

Share this article with a friend:

Get emailed clinical trial results in the categories of your choice:
Free subscription to clinical trial results

20,000 clinical trials are seeking participants.
Signup and be matched to trials near you
This free service will notify you of current and future clinical trial matches.

This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.