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Treating Advanced Colon Cancer with HIPEC Therapy


Clinical trial shows adding HIPEC after surgery improves outcomes for colon cancer patients

Dealing with advanced colon cancer, especially at its toughest stage (T4), has always been tricky due to the high chance of the disease coming back even after surgery. However, a clinical trial conducted across 17 centers in Spain might have found a way to make things better: a treatment called Hyperthermic Intraperitoneal Chemotherapy (HIPEC). Let's learn what this research revealed and how it could improve outcomes for people with advanced colon cancer.


Clinical trial

From November 2015 to March 2021, researchers enrolled individuals aged 18 to 75 diagnosed with advanced colon cancer. They split these patients into two groups: one group got surgery plus HIPEC with a specific chemotherapy drug, and the other group only had surgery. Both groups then got more chemotherapy after the surgery.



The main thing they wanted to check was how many people stayed free from the disease coming back in their abdomen for three years after treatment. The results showed a much better rate (97.6%) in the group that got HIPEC compared to the group that only had surgery (87.6%). This was especially true for patients with the toughest stage of the disease (98.3% vs. 82.1%).


Even though there weren't big differences in how long people lived without the disease returning or in their overall survival between the two groups, the huge improvement in controlling the disease in the peritoneum is important. The peritoneum is a thin layer, like a sheet, that covers and protects the organs in your belly (abdominal cavity). It helps keep everything in place and allows organs to move smoothly without rubbing against each other. The trial suggests that adding HIPEC after surgery could help lower the chances of the disease coming back in that area.

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The trial didn't see any big differences in how sick people felt or in any bad effects between the two groups. This is important because it means that adding HIPEC after surgery didn't cause big extra problems or risks compared to just having surgery.


These findings are a big deal in how we handle advanced colon cancer. Adding HIPEC after surgery seems to help control the disease in the peritoneum, especially in stopping it from coming back there.



Using Hyperthermic Intraperitoneal Chemotherapy (HIPEC) after full surgery for advanced colon cancer has shown promising results, particularly in controlling the disease in the peritoneum for three years. While more studies are needed to see how it affects long-term survival, this treatment option is making things better for people dealing with late-stage colon cancer.


JAMA Network, Apr-26-23
ClinicalTrials.gov,  NCT02614534

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.