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Hydroxyurea Effectively Reduces Stroke Risk in Children with Sickle Cell Anemia


Clinical trial finds that hydroxyurea is effective in reducing stroke risk in children with sickle cell anemia

Clinical trials are important studies that test new treatments or therapies on humans to see if they are effective and safe. In this particular clinical trial, doctors wanted to test a new treatment for children with sickle cell anemia in Tanzania, a country in East Africa.

Sickle cell anemia is a genetic condition where the red blood cells are shaped like a sickle or a crescent moon. This shape makes it harder for the blood to flow through the blood vessels, causing a range of health problems, including an increased risk of stroke. In Tanzania, it is especially difficult to detect and treat sickle cell anemia, and doctors have limited resources to prevent strokes in children.

The doctors wanted to see if a medication called hydroxyurea could help prevent strokes in children with sickle cell anemia. Hydroxyurea is a drug that has been used to treat cancer, but it can also increase the production of healthy red blood cells in sickle cell anemia patients. The doctors also used a test called transcranial Doppler ultrasound to measure the blood flow in the children's brains and determine their stroke risk.

Clinical Trial

The trial was conducted at Bugando Medical Centre in Mwanza, Tanzania, and involved 202 children between the ages of 2 and 16. The children were diagnosed with sickle cell anemia through a blood test that looked at their hemoglobin, a protein in the blood that carries oxygen.

During the study, the children underwent transcranial Doppler ultrasound tests to check their blood flow in the brain. If the test showed that they had a high risk of stroke, they were given hydroxyurea. If their risk was low, they received the usual care from the sickle cell clinic and were checked again after 12 months to see if they needed the medication.

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The primary goal of the study was to see if the medication could lower the risk of stroke by reducing the blood flow velocity in the brain. After 12 months of taking hydroxyurea, the children who received the medication had a significant reduction in blood flow velocity, compared to those who did not receive it. This reduction in velocity means that the blood was flowing more smoothly through their blood vessels, reducing the risk of a stroke.

Importantly, none of the children in the study had a stroke while taking the medication, and there were no serious side effects related to the medication. The most common side effects were mild and included malaria and sepsis, which are common health issues in Tanzania.

The results of the study show that hydroxyurea is an effective medication for reducing the risk of stroke in children with sickle cell anemia. This is particularly important in low-resource areas like Tanzania, where it is difficult to perform regular transcranial Doppler ultrasound tests to screen for stroke risk. The medication can also be more accessible and less expensive than regular screenings.


This clinical trial showed that hydroxyurea is an effective and safe medication for preventing strokes in children with sickle cell anemia. This medication can provide an important treatment option in areas where regular screenings for stroke risk may not be feasible. Future studies can continue to explore the use of hydroxyurea and other treatments to improve the lives of those living with sickle cell anemia.


THE LANCET, Mar-01-23

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.