Breast cancer is a serious health issue that affects millions of people around the world. Given the number of treatment options available, it can be difficult for doctors and patients to determine the best course of action to reduce the risk of recurrence.
A clinical trial has been conducted to investigate the association between regional lymph node radiotherapy and breast cancer recurrence for patients with low-risk breast cancer.
Breast cancer is one of the most common types of cancer affecting women worldwide.
When breast cancer is diagnosed, doctors have to determine the severity of the cancer and the appropriate treatment options.
Lymph nodes are small glands that filter lymph, the fluid in our immune system. The lymph nodes are part of the body's immune system and are connected by lymphatic vessels. They play a crucial role in filtering out harmful substances and fighting off infections. When breast cancer spreads, it often travels to the lymph nodes first. Therefore, treating the lymph nodes with radiation therapy can help prevent cancer from recurring.
Regional nodal irradiation is a type of treatment that involves focusing radiation on the lymph nodes surrounding the breast. Radiation therapy uses high-energy X-rays to destroy cancer cells. However, its benefit in reducing cancer recurrence after surgery in low-risk women is unknown.
Clinical TrialThis trial examines the relationship between regional lymph node irradiation and breast cancer recurrence-free interval for patients with low-risk, node-positive breast cancer.
The trial involved 1,169 patients who had been diagnosed with low-risk breast cancer and had undergone surgery. Of these patients, 151 women did not receive radiation while 133 women received radiotherapy to the breast alone. In the remaining 885 patients, radiation therapy was given to the local lymph nodes as well. These women were followed up for an average of 9.2 years to detect breast cancer recurrence.