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Clinical Trial Shows Upadacitinib Reduces Joint Damage in Rheumatoid Arthritis


Clinical trial shows upadacitinib reduces joint damage in rheumatoid arthritis

A clinical trial investigated the safety and effectiveness of a new drug called upadacitinib in reducing structural joint damage in patients with rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints, causing pain, swelling, and stiffness. Over time, RA can lead to joint damage, which can severely impact a person's quality of life. There are many drugs currently in use for this debilitating disease. Research suggests that a drug called upadacitinib may be able to slow down the progression of joint damage in people with RA.

Upadacitinib works by inhibiting a protein called Janus kinase (JAK), which is involved in the immune response that causes RA. By blocking JAK, upadacitinib can reduce inflammation and slow down the progression of joint damage. However, strong clinical evidence demonstrating the long-term effectiveness of upadacitinib was deficient.

A clinical trial investigated the benefit of using upadacitinib for reducing joint damage in rheumatoid arthritis patients.

The trial involved 2,574 patients with rheumatoid arthritis enrolled in two ongoing clinical trials. These patients were divided into groups and received either methotrexate alone or in combination with upadacitinib or a placebo. Structural joint damage was determined at the end of 48 weeks by using modified total Sharp score, joint space narrowing, and erosion scores.

After one year, the researchers found that the group of patients who received upadacitinib had significantly less progression of joint damage than the group that received a placebo or methotrexate alone. The joint x-rays done at 1 year demonstrated that upadacitinib significantly inhibited the progression of structural joint damage in these rheumatoid arthritis patients.

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These results are significant because they suggest that upadacitinib may be able to slow down the damage that RA does to the joints. This could help people with RA to maintain their mobility and quality of life for longer periods. The results of this study are promising and suggest that upadacitinib could be a valuable treatment option for people with RA.


Upadacitinib may be a valuable treatment option for people with RA who want to slow down the progression of joint damage. The results of this clinical trial provide further support that upadacitinib can significantly reduce joint damage in people with RA, helping them to maintain an active lifestyle and improve their quality of life. If you or a loved one have RA, it's important to talk to your doctor about all of your treatment options, including upadacitinib. Your doctor can help you determine if upadacitinib is right for you based on your individual needs and medical history.

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.