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Clinical Trial finds Oxytocin Nasal Spray gives New Hope for Meth Addicted


Oxytocin shown to have therapeutic effect on METH-addicted patients

Drug addiction is a serious problem that affects many people around the world. One of the drugs that is increasingly becoming a public health concern is methamphetamine (METH). METH dependence has many negative effects on both mental and physical health. In a clinical trial, oxytocin (OXT) has been shown to have therapeutic properties in treating drug dependence, including METH dependence. This clinical trial evaluated the effects of OXT on METH-dependent patients undergoing a Matrix Treatment Model (MTM).

What is OXT?

So, what is OXT (Oxytocin), and how does it work in treating drug addiction? OXT is a hormone that is naturally produced by the body, and it is often referred to as the "love hormone" or "cuddle hormone" because it is released during social bonding activities like hugging or kissing. OXT has been shown to have various effects on the brain, including reducing stress, anxiety, and depression. Studies have also suggested that OXT can reduce drug cravings and improve treatment outcomes in individuals with drug addiction.

Matrix Treatment Model

MTM (Matrix Treatment Model) is an evidence-based treatment approach that focuses on treating drug addiction as a chronic medical illness. It involves individual and group counseling sessions, cognitive-behavioral therapy, and contingency management. The goal of MTM is to help patients achieve and maintain abstinence from drug use while improving their overall quality of life.

Clinical Trial

The study looked at 42 people who were addicted to METH. They were being treated with an outpatient program called MTM. The researchers divided the people into two groups randomly. One group got a nasal spray with OXT, while the other group got a spray with salt water. They used the sprays for four weeks. The researchers checked the patients' health at the beginning and end of the study. They found that the people who used the OXT spray had fewer cravings for the drug and felt less sad than the people who used the saltwater spray. However, there was no difference in how anxious the two groups felt. The OXT spray also lowered the levels of two hormones related to stress (Cortisol and ACTH).

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These findings suggest that OXT could be a new potential therapeutic option for treating METH-dependent patients undergoing MTM. However, further studies are needed to explore the effectiveness and safety of OXT.



This clinical trial provides evidence that OXT could be a potential new therapeutic option for treating METH-dependent patients undergoing MTM. The study showed that OXT administration was associated with a significant improvement in craving and depression scores in METH-dependent patients, as well as a decrease in cortisol and ACTH levels.

However, further studies are needed to explore the effectiveness and safety of OXT in treating drug addiction. If OXT proves to be an effective treatment option, it could provide hope to many individuals struggling with drug addiction and improve their chances of successful recovery.


Karger, Sep-22

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This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.