CenTrial Logo

About Parkinson's Disease


Parkinson's disease is a neurological disorder that affects millions of people worldwide. It is characterized by tremors, stiffness, and difficulty with movement. Understanding Parkinson's disease is key because it allows individuals and their loved ones to better manage the condition and seek appropriate treatment.

As Parkinson's disease can have a significant impact on daily life, it is important to recognize its symptoms early on. By understanding the disease, individuals can take proactive steps to improve their quality of life and seek support from healthcare professionals.

One valuable resource for individuals with Parkinson's disease is CenTrial.org. CenTrial is a platform dedicated to matching individuals with relevant clinical trials related to Parkinson's disease. Clinical trials play a vital role in advancing medical research and developing new treatments for Parkinson's disease.

By connecting people with clinical trials, CenTrial empowers them to play an active role in advancing Parkinson's disease research and finding potential treatments. 

About Parkinson's disease

What is Parkinson’s disease?

Parkinson's disease is a progressive neurological disorder that affects movement. It develops gradually over time and is caused by the gradual loss of nerve cells in the brain that produce dopamine, a chemical messenger involved in controlling movement.
Parkinson's disease was named after Dr. James Parkinson, who first described it in 1817. It is characterized by a combination of motor symptoms, such as tremors, rigidity, bradykinesia (slowed movement), and postural instability.

Symptoms of Parkinson's Disease

The symptoms of Parkinson's disease can vary from person to person and may include:
  • Tremors: Involuntary shaking, usually starting in the hands or fingers.
  • Rigidity: Stiffness and inflexibility of the limbs and trunk, making movement difficult.
  • Bradykinesia: Slowed movement and difficulty initiating movement.
  • Postural instability: Impaired balance and coordination, leading to a tendency to fall.
Other symptoms may include changes in speech, writing, and facial expressions.

Causes and Risk Factors of Parkinson’s Disease

The exact cause of Parkinson's disease is still unknown, but it is believed to involve a combination of genetic and environmental factors. Some potential risk factors for Parkinson's disease may include:
  • Age: The risk of developing Parkinson's disease increases with age, with most cases diagnosed in individuals over the age of 60.
  • Genetics: While most cases of Parkinson's disease are sporadic, meaning they occur randomly, a small percentage of cases are believed to be inherited.
  • Environmental factors: Exposure to certain toxins or environmental pollutants may increase the risk of developing Parkinson's disease.
  • Other factors: Some research suggests that factors such as head injuries, rural living, and certain medications may also be associated with an increased risk of Parkinson's disease.
Understanding the causes and risk factors of Parkinson's disease is essential for early detection and management of the condition.

Stages of Parkinson's Disease

Parkinson's disease progresses through different stages, each with its own set of symptoms and challenges. While the progression of Parkinson's disease can vary from person to person, it generally follows a predictable pattern.

Stage 1: In the early stages, symptoms may be mild and may not interfere significantly with daily activities. Tremors or other motor symptoms may be present on one side of the body.

Stage 2: Symptoms become more noticeable and may affect both sides of the body. Daily tasks may become more challenging, but individuals can still live independently.

Stage 3: Symptoms become more pronounced and may significantly impact daily life. Balance and coordination issues may increase the risk of falls.

Stage 4: Symptoms are severe, and individuals may require assistance with daily activities. Mobility may be severely affected, and falls are common.

Stage 5: This is the most advanced stage of Parkinson's disease. Individuals may be unable to walk or stand without assistance and may require round-the-clock care.

Understanding the stages of Parkinson's disease can help individuals and their caregivers anticipate changes and plan for appropriate care and support.

Treatment of Parkinson's Disease

There are several medications available to help manage the symptoms of Parkinson's disease. These medications work by either increasing dopamine levels in the brain or mimicking the effects of dopamine. Some common medications used to treat Parkinson's disease are:
  • Levodopa: This medication is converted into dopamine in the brain and helps alleviate symptoms such as tremors, rigidity, and bradykinesia.
  • Dopamine agonists: These medications mimic the effects of dopamine in the brain and can help improve motor symptoms.
  • MAO-B inhibitors: These medications help prevent the breakdown of dopamine in the brain, thereby increasing dopamine levels and improving symptoms.
  • COMT inhibitors: These medications prolong the effects of levodopa by preventing its breakdown in the body.

In addition to medication, there are various treatment options and management strategies available to help individuals with Parkinson's disease live well with the condition, such as:
  • Physical therapy: Exercise and physical therapy can help improve flexibility, balance, and overall mobility in individuals with Parkinson's disease.
  • Occupational therapy: Occupational therapy focuses on helping individuals maintain independence in daily activities by teaching adaptive strategies and techniques.
  • Speech therapy: Speech therapy can help individuals with Parkinson's disease improve speech and communication difficulties that may arise.
  • Deep brain stimulation (DBS): DBS is a surgical procedure that involves implanting electrodes in the brain to help regulate abnormal brain activity and alleviate symptoms.
  • Lifestyle modifications: Making lifestyle changes such as maintaining a healthy diet, getting regular exercise, and managing stress can help improve overall well-being and symptom management.
By combining medication with various treatment options and management strategies, individuals with Parkinson's disease can effectively manage their symptoms and maintain a good quality of life.

Self-Care Tips and Strategies for Parkinson’s Disease

Self-care is essential for individuals living with Parkinson's disease to manage their symptoms and maintain overall well-being. Here are some self-care tips and strategies:

Stay active: Regular exercise, such as walking, swimming, or tai chi, can help improve flexibility, balance, and mobility. Aim for at least 30 minutes of moderate exercise most days of the week.

Eat a balanced diet: A healthy diet rich in fruits, vegetables, whole grains, and lean proteins can help support overall health and well-being. Be sure to stay hydrated and limit your intake of processed foods and sugary snacks.

Get enough rest: Adequate sleep is important for managing symptoms of Parkinson's disease. Establish a regular sleep schedule, create a relaxing bedtime routine, and create a comfortable sleep environment.

Manage stress: Stress can exacerbate symptoms of Parkinson's disease, so it's important to find ways to relax and unwind. Practice relaxation techniques such as deep breathing, meditation, or yoga.

Stay socially connected: Maintain relationships with friends and family members for emotional support and companionship. Join a support group or participate in community activities to connect with others who understand your experiences.

Adapt your environment: Make modifications to your home environment to make daily tasks easier and safer. Consider installing grab bars, handrails, or ramps to prevent falls and accidents.

Factors That Worsen Parkinson's Disease

Several factors can exacerbate symptoms of Parkinson's disease and may need to be managed or avoided. These include:

  • Stress: Stress can trigger or worsen symptoms of Parkinson's disease, so it's important to find healthy ways to manage stress and reduce its impact on your life.
  • Illness or infection: Illnesses such as the flu or infections can worsen Parkinson's symptoms temporarily. Be sure to practice good hygiene, get vaccinated as recommended, and seek prompt medical attention if you develop any signs of illness.
  • Medication changes: Changes in medication dosage or timing can affect symptom control in individuals with Parkinson's disease. Always follow your healthcare provider's instructions when taking medication and report any changes in symptoms.
  • Fatigue: Fatigue is common in Parkinson's disease and can worsen symptoms such as tremors, stiffness, and slowness of movement. Be sure to get enough rest and conserve energy throughout the day.
  • Environmental factors: Extreme temperatures, loud noises, or crowded environments can worsen symptoms of Parkinson's disease. Avoid situations that may exacerbate symptoms or take steps to minimize their impact.

Common Concerns and Questions Regarding Parkinson’s Disease

What is the life expectancy of Parkinson's Disease?

Parkinson's disease itself does not directly affect life expectancy. However, complications related to Parkinson's disease, such as pneumonia, falls, and aspiration pneumonia, can impact life expectancy. With proper management and treatment, many individuals with Parkinson's disease can live for many years after diagnosis.

Does Parkinson's affect memory?

Parkinson's disease primarily affects movement-related symptoms, but some individuals may also experience cognitive changes, including difficulties with memory, attention, and executive function. These cognitive changes can vary from person to person and may not affect everyone with Parkinson's disease. However, it's essential to monitor cognitive function and seek support from healthcare professionals if memory problems arise.

How do you stop Parkinson's from progressing?

While there is currently no cure for Parkinson's disease, several treatment options and management strategies can help slow the progression of symptoms and improve quality of life. These may include medication, physical therapy, occupational therapy, speech therapy, deep brain stimulation (DBS), and lifestyle modifications. Early diagnosis and proactive management are key to slowing disease progression and maintaining independence.

What are signs that Parkinson's is getting worse?

Signs that Parkinson's disease may be progressing include an increase in the severity or frequency of motor symptoms such as tremors, stiffness, slowness of movement, and difficulty with balance and coordination. Changes in mood, cognition, or behavior may also indicate disease progression. It's important to communicate any changes in symptoms to healthcare providers to adjust treatment plans accordingly.

Can you prevent Parkinson’s Disease?

While there is currently no known way to prevent Parkinson's disease entirely, there are steps individuals can take to potentially reduce their risk of developing the condition.

Maintain a Healthy Lifestyle

Eating a balanced diet rich in fruits, vegetables, whole grains, and lean proteins can support overall health and may help reduce the risk of developing chronic diseases like Parkinson's. Regular exercise, such as walking, swimming, or cycling, can also help maintain a healthy weight and improve cardiovascular health.

Protect Your Brain

Engaging in activities that stimulate the brain, such as reading, puzzles, and social interactions, may help maintain cognitive function and reduce the risk of developing neurological conditions like Parkinson's disease. Protecting the brain from head injuries by wearing helmets during sports and avoiding activities with a high risk of falls can also help minimize the risk of developing Parkinson's disease.

Avoid Toxins

Some research suggests that exposure to certain environmental toxins, such as pesticides and herbicides, may increase the risk of developing Parkinson's disease. Minimizing exposure to these toxins by using protective equipment and following safety guidelines in the workplace and home environment may help reduce the risk of developing Parkinson's disease.

Monitor Your Health

Regular medical check-ups can help monitor overall health and detect any potential risk factors or early signs of Parkinson's disease. Individuals with a family history of Parkinson's or other neurological conditions may benefit from discussing their risk with a healthcare provider and exploring options for early detection and intervention.

While these strategies may help reduce the risk of developing Parkinson's disease, it's essential to remember that not all risk factors are controllable, and some individuals may still develop the condition despite taking preventive measures. However, adopting a healthy lifestyle and minimizing exposure to environmental toxins can support overall health and well-being, potentially reducing the risk of developing Parkinson's disease and other chronic conditions.

Clinical Trials for Parkinson's Disease

Clinical trials play a fundamental role in advancing research and treatment options for Parkinson's disease. These studies help researchers test new medications, therapies, and interventions to improve symptoms, slow disease progression, and enhance the quality of life for individuals with Parkinson's disease. By participating in clinical trials, individuals have the opportunity to contribute to medical knowledge and potentially benefit from cutting-edge treatments not yet available to the public.

Role of CenTrial in Matching Individuals with Parkinson's Disease Clinical Trials

CenTrial.org serves as a valuable resource for individuals with Parkinson's disease by matching them with relevant clinical trials tailored to their specific needs and preferences. CenTrial utilizes a sophisticated matching process to connect individuals with Parkinson's disease to clinical trials that align with their medical history, symptoms, and preferences.

After signing up on the platform, users complete a health profile to provide information about their health status and specific interests regarding clinical trials. CenTrial then uses this information to generate personalized notifications about clinical trials that may be suitable for each individual.

CenTrial's matching process considers various factors, including the individual's location, medical history, disease stage, and preferences for participation. Through its user-friendly interface, CenTrial delivers personalized notifications to users, alerting them about clinical trials that match their criteria. These notifications provide comprehensive details about each trial, including eligibility requirements, and study objectives, enabling individuals to make informed decisions about participation.

Benefits of Participating in Clinical Trials

Participating in clinical trials through CenTrial.org offers several potential benefits for individuals with Parkinson's disease:

  • Access to cutting-edge treatments: Clinical trials offer potential access to innovative medications, therapies, or interventions not yet available to the public, providing individuals with Parkinson's disease with an opportunity to explore new treatment options and potentially improve their symptoms.
  • Contribution to medical research: By participating in clinical trials, individuals with Parkinson's disease can contribute to the advancement of medical knowledge and the development of new treatments for the condition, ultimately benefiting future generations of patients.


Parkinson's disease is a progressive neurological disorder characterized by motor symptoms such as tremors, rigidity, and difficulty with movement. While there is currently no cure for Parkinson's disease, various medications, treatments, and management strategies are available to help individuals manage their symptoms and maintain quality of life. Individuals with Parkinson's disease and their caregivers need to stay informed about the condition, seek support from healthcare professionals, and explore available resources for managing the disease effectively.

Research plays a crucial role in advancing our understanding of Parkinson's disease and developing new treatments and interventions to improve outcomes for individuals living with the condition. By participating in clinical trials and supporting research efforts, people with Parkinson's disease can contribute to the development of new therapies and ultimately help find a cure for the disease. Additionally, raising awareness about Parkinson's disease and its impact on individuals and families can aid in early diagnosis, access to treatment, and support services.

For those with Parkinson's disease who are interested in exploring new treatment options and contributing to medical research, CenTrial.org offers a valuable platform for participating in clinical trials. By signing up on CenTrial, individuals can receive personalized notifications about clinical trials that may be suitable for them, empowering them to take an active role in their healthcare and potentially benefit from advanced treatments.
Promising Results in Alleviating Parkinson’s Symptoms
Managing Impulse Control Disorders in Parkinson's Disease
Natural Remedies for Parkinson's: Bacopa monnieri Extract
Tackling Gait Deficits in Parkinson's Disease with Treadmill Training
Prebiotics and Probiotics Improve Quality of Life for Parkinson's Patients
Managing Parkinson's Disease with Mindfulness Meditation
Exercise can Improve Symptoms of Parkinson’s Disease
Clinical Trial Explores Acupuncture as Treatment for Anxiety in Parkinson's Patients
If People do not Participate in Clinical Trials, there will be no Cure

This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. CenTrial Data Ltd. does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Treatments and clinical trials mentioned may not be appropriate or available for all trial participants. Outcomes from treatments and clinical trials may vary from person to person. Consult with your doctor as to whether a clinical trial is a suitable option for your condition. Assistance from generative AI tools may have been used in writing this article.
Find a Trial