Funding for Medical Research
and Clinical Trials
and Clinical Trials
Funding Details for Neurological
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Addiction/Substance Abuse, Obesity, Multiple/Comorbid Chronic Conditions, Mental/Behavioral Health, Depression or Anxiety
Patient-Centered Outcomes Research Institute (PCORI)
Type of Organization: Foundation
Email Address: sciencequestions@pcori.org
Funds Available for Clinical Trials: ✔ Research: ✔
1) Prevention and treatment of obesity
Obesity is a complex disease associated with sequelae that can impair a child’s well-being and quality of life during a critical time for growth and development. Rates of pediatric obesity remain high in the United States and disproportionally affect Black and Hispanic or Latino/a youth and those from low-income households. PCORI is interested in funding CER studies comparing evidence-based obesity prevention and treatment approaches for children and adolescents, including dietary, physical activity, lifestyle modification, behavioral, psychosocial, adjunctive pharmacologic or surgical, and/or combination approaches, as appropriate. Proposed prospective interventional studies should include a multicomponent intervention that utilizes combination strategies of nutrition, physical activity or psychosocial support, and/or a multilevel intervention that targets individual, family and socio-contextual factors related to obesity. At least one primary outcome should be an obesity-related outcome, such as a recommended child adiposity/anthropometric measurement, and is strongly encouraged to be measured for a minimum of 24 months from baseline. Populations disproportionally affected by childhood obesity as well as under-researched populations are especially of interest.
2) Addressing social determinants of health/social needs to improve health outcomes
Children and youth constitute the poorest segment of the U.S. population. Poverty, and its associated social and structural drivers are significant upstream causes of child morbidity and mortality. Thus, interventions that identify and address social determinants of health (SDOH) and social needs are important to modify health-related risks that contribute to chronic illness and health inequities and prevent future health conditions in children and youth. PCORI is interested in funding CER studies comparing interventions to address SDOH and/or social needs (e.g., housing instability and quality, food insecurity) to improve the health outcomes of children and youth. Appropriate interventions of interest to PCORI to address SDOH/social needs include adjustment, assistance, and alignment interventions, as defined in the National Academies of Sciences, Engineering and Medicine committee report entitled Integrating Social Needs Care Into the Delivery of Health Care To Improve the Nation’s Health1. Interventions should be designed to address one or more social needs in the following domains: food insecurity, transportation, housing, education, child care and financial strain. Interventions may be delivered in the clinical and/or community setting but must have a link to the healthcare system. Studies with an intervention arm that solely involves the introduction of a Community Health Worker (CHW) or a patient navigator will be considered non-responsive; in contrast, studies in which a CHW or patient navigation is embedded in research questions addressing SDOH/social needs and organizational interventions are acceptable. Research teams should strive to partner with public health and/or community-based organizations and should propose to include a study sample that is inclusive of diverse and underrepresented patient populations. Studies should include a health outcome (e.g., physical or mental health status, health-related quality of life) as the primary outcome.
3) Targeted prevention of substance misuse through identified risk factors
Adolescence is a critical period for physical and psychological development and is also a susceptible time for the initiation of substance misuse. Timely targeted prevention approaches are imperative to avoid and address substance misuse as early as possible and mitigate associated negative outcomes. PCORI is interested in funding CER that compares individual-, provider- and/or clinic-level interventions that optimize pain management for children and youth and reduce risk for sustained prescription opioid use or misuse post-injury/post-trauma (e.g., screening, perioperative pain management education and guidelines). PCORI is also interested in funding CER studies comparing evidence-based approaches that can prevent substance misuse, substance use disorder (SUD), or substance use-related harms in children and youth with adverse childhood experiences (ACEs) or other identified risk factors. Studies could include selective or indicated evidence-based prevention interventions. Applicants may propose studies targeting other groups of children and youth at elevated risk of substance misuse or substance-use-related harms due to other identified risk factors, as long as the need for patient-centered CER on approaches to prevent substance misuse/substance use-related harm in the target population(s) is sufficiently justified. At least one primary outcome should focus on substance misuse. Outcomes that are measured objectively and assessed at least 12 months after baseline are encouraged when appropriate.
Other info: The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a PCORI Topical Funding Announcement (PFA) on Sept. 4, 2024, seeking to fund patient-centered comparative clinical effectiveness research (CER) projects that focus on interventions that improve patient-centered outcomes in children and youth. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and create responsive, high-quality proposals.
MAXIMUM PROJECT PERIOD: Up to five years
Patient-Centered Outcomes Research Institute (PCORI)
Type of Organization: Foundation
Email Address: sciencequestions@pcori.org
Funds Available for Clinical Trials: ✔ Research: ✔
Funding Details
Requirements: PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAEs). The purpose of identifying these SAEs is to encourage submissions to these areas, not to limit submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach.1) Prevention and treatment of obesity
Obesity is a complex disease associated with sequelae that can impair a child’s well-being and quality of life during a critical time for growth and development. Rates of pediatric obesity remain high in the United States and disproportionally affect Black and Hispanic or Latino/a youth and those from low-income households. PCORI is interested in funding CER studies comparing evidence-based obesity prevention and treatment approaches for children and adolescents, including dietary, physical activity, lifestyle modification, behavioral, psychosocial, adjunctive pharmacologic or surgical, and/or combination approaches, as appropriate. Proposed prospective interventional studies should include a multicomponent intervention that utilizes combination strategies of nutrition, physical activity or psychosocial support, and/or a multilevel intervention that targets individual, family and socio-contextual factors related to obesity. At least one primary outcome should be an obesity-related outcome, such as a recommended child adiposity/anthropometric measurement, and is strongly encouraged to be measured for a minimum of 24 months from baseline. Populations disproportionally affected by childhood obesity as well as under-researched populations are especially of interest.
2) Addressing social determinants of health/social needs to improve health outcomes
Children and youth constitute the poorest segment of the U.S. population. Poverty, and its associated social and structural drivers are significant upstream causes of child morbidity and mortality. Thus, interventions that identify and address social determinants of health (SDOH) and social needs are important to modify health-related risks that contribute to chronic illness and health inequities and prevent future health conditions in children and youth. PCORI is interested in funding CER studies comparing interventions to address SDOH and/or social needs (e.g., housing instability and quality, food insecurity) to improve the health outcomes of children and youth. Appropriate interventions of interest to PCORI to address SDOH/social needs include adjustment, assistance, and alignment interventions, as defined in the National Academies of Sciences, Engineering and Medicine committee report entitled Integrating Social Needs Care Into the Delivery of Health Care To Improve the Nation’s Health1. Interventions should be designed to address one or more social needs in the following domains: food insecurity, transportation, housing, education, child care and financial strain. Interventions may be delivered in the clinical and/or community setting but must have a link to the healthcare system. Studies with an intervention arm that solely involves the introduction of a Community Health Worker (CHW) or a patient navigator will be considered non-responsive; in contrast, studies in which a CHW or patient navigation is embedded in research questions addressing SDOH/social needs and organizational interventions are acceptable. Research teams should strive to partner with public health and/or community-based organizations and should propose to include a study sample that is inclusive of diverse and underrepresented patient populations. Studies should include a health outcome (e.g., physical or mental health status, health-related quality of life) as the primary outcome.
3) Targeted prevention of substance misuse through identified risk factors
Adolescence is a critical period for physical and psychological development and is also a susceptible time for the initiation of substance misuse. Timely targeted prevention approaches are imperative to avoid and address substance misuse as early as possible and mitigate associated negative outcomes. PCORI is interested in funding CER that compares individual-, provider- and/or clinic-level interventions that optimize pain management for children and youth and reduce risk for sustained prescription opioid use or misuse post-injury/post-trauma (e.g., screening, perioperative pain management education and guidelines). PCORI is also interested in funding CER studies comparing evidence-based approaches that can prevent substance misuse, substance use disorder (SUD), or substance use-related harms in children and youth with adverse childhood experiences (ACEs) or other identified risk factors. Studies could include selective or indicated evidence-based prevention interventions. Applicants may propose studies targeting other groups of children and youth at elevated risk of substance misuse or substance-use-related harms due to other identified risk factors, as long as the need for patient-centered CER on approaches to prevent substance misuse/substance use-related harm in the target population(s) is sufficiently justified. At least one primary outcome should focus on substance misuse. Outcomes that are measured objectively and assessed at least 12 months after baseline are encouraged when appropriate.
Other info: The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a PCORI Topical Funding Announcement (PFA) on Sept. 4, 2024, seeking to fund patient-centered comparative clinical effectiveness research (CER) projects that focus on interventions that improve patient-centered outcomes in children and youth. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and create responsive, high-quality proposals.
MAXIMUM PROJECT PERIOD: Up to five years